Grayanane diterpenoids from Craibiodendron yunnanense with anti-inflammatory and antinociceptive activities

被引：3

作者：

Li, Qian ^{[1
,2
]}

Guo, Yan ^{[1
,2
]}

Wei, Di ^{[3
]}

Gong, Lvdong ^{[1
,2
]}

Feng, Liping ^{[1
,2
]}

Dong, Xun ^{[1
,2
]}

Cui, Tao ^{[1
,2
]}

机构：

[1] Yunnan Inst Mat Med, Kunming 650111, Peoples R China

[2] Yunnan Prov Co Key Lab TCM & Ethn Drug New Drug Cr, Kunming 650111, Peoples R China

[3] Guizhou Yibai Pharmaceut Co, Guiyang 551405, Peoples R China

来源：

PHYTOCHEMISTRY | 2023年 / 212卷

关键词：

Ericaceae; Grayanane diterpenoids; Anti-inflammatory activity; Antinociceptive activity; Structure-activity relationships; Craibiodendron yunnanense W; W; Smith; PIERIS-JAPONICA; LEAVES; CONSTITUENTS; GLUCOSIDE; FLOWERS; ROOTS;

D O I：

10.1016/j.phytochem.2023.113729

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twenty-five grayanane diterpenoids including six undescribed compounds (craibiodenoside A-F), were isolated from the leaves of Craibiodendron yunnanense W. W. Smith. The structures of the isolated compounds were determined by 1D-NMR, 2D-NMR, and HR-ESI-MS spectrometric analyses. All compounds were evaluated for their anti-inflammatory activities by inhibiting the release of interleukin-6 (IL-6) in lipopolysaccharide (LPS)induced RAW264.7 cells. The results demonstrated that three undescribed compounds craibiodenoside A, B, F, and three known compounds could inhibit the release of IL-6 significantly. In addition, the antinociceptive activities of compounds were assessed using acetic acid-induced writhing test. Craibiodenoside D, grayanoside D, and rhodojaponins VI exhibited notable antinociceptive activities. Specifically, rhodojaponins VI exhibited antinociceptive activity with the inhibition percentage of 87.6%.

引用

页数：8

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