Association of self-identified race and genetic ancestry with the immunogenomic landscape of primary prostate cancer

被引：3

作者：

Vidotto, Thiago ^{[1
]}

Imada, Eddie L. ^{[2
]}

Faisal, Farzana ^{[1
]}

Murali, Sanjana ^{[1
]}

Mendes, Adrianna A. ^{[1
]}

Kaur, Harsimar ^{[1
]}

Zheng, Siqun ^{[3
]}

Xu, Jianfeng ^{[3
]}

Schaeffer, Edward M. ^{[4
]}

Isaacs, William B. ^{[5
]}

Sfanos, Karen S. ^{[1
]}

Marchionni, Luigi ^{[2
,6
,7
]}

Lotan, Tamara L. ^{[1
,5
,6
,7
,8
]}

机构：

[1] Johns Hopkins Univ, Dept Pathol, Sch Med, Baltimore, MD USA

[2] Weill Cornell Sch Med, Dept Pathol, New York, NY USA

[3] NorthShore Univ Hlth Syst, Program Personalized Canc Care, Evanston, IL USA

[4] Northwestern Univ, Dept Urol, Sch Med, Chicago, IL USA

[5] Johns Hopkins Univ, Dept Urol, Sch Med, Baltimore, MD USA

[6] Johns Hopkins Univ, Sch Med, Dept Urol, Baltimore, MD USA

[7] Johns Hopkins Univ, Dept Oncol, Sch Med, Baltimore, MD USA

[8] 1550 Orleans St, Baltimore, MD 21231 USA

来源：

JCI INSIGHT | 2023年 / 8卷 / 03期

关键词：

AFRICAN-AMERICAN; PTEN LOSS; METASTASIS; SUBSEQUENT; DELETION; TUMORS; MEN;

D O I：

10.1172/jci.insight.162409

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The genomic and immune landscapes of prostate cancer differ by self-identified race. However, few studies have examined the genome-wide copy number landscape and immune content of matched cohorts with genetic ancestry data and clinical outcomes. Here, we assessed prostate cancer somatic copy number alterations (sCNA) and tumor immune content of a grade-matched, surgically treated cohort of 145 self-identified Black (BL) and 145 self-identified White (WH) patients with genetic ancestry estimation. A generalized linear model adjusted with age, preoperative prostate-specific antigen (PSA), and Gleason Grade Group and filtered for germline copy number variations (gCNV) identified 143 loci where copy number varied significantly by percent African ancestry, clustering on chromosomes 6p, 10q, 11p, 12p, and 17p. Multivariable Cox regression models adjusted for age, preoperative PSA levels, and Gleason Grade Group revealed that chromosome 8q gains (including MYC) were significantly associated with biochemical recurrence and metastasis, independent of genetic ancestry. Finally, Treg density in BL and WH patients was significantly correlated with percent genome altered, and these findings were validated in the TCGA cohort. Taken together, our findings identify specific sCNA linked to genetic ancestry and outcome in primary prostate cancer and demonstrate that Treg infiltration varies by global sCNA burden in primary disease.

引用

页数：17

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