Hydroxy-Containing Covalent Organic Framework Combined with Nickel Ferrite as a Platform for the Recognition and Capture of Bisphenols

A hydroxy-containing covalent organic framework (COF) was successfully obtained via a simple nitrogen-purge synthetic procedure for the first time. The COF favored a serrated AA-stacking arrangement, which enhanced the stability compared with common AA or AB arrangements. To validate the potential of the COF in environmental applications, we decorated the COF onto NiFe2O4 and used the NiFe2O4@COF nanocomposite for magnetic solid-phase extraction of trace bisphenols (BPs). The parameters affecting extraction efficiencies were systematically optimized. Under the optimum extraction conditions, calibration plots showed good linearity (5.0-1.0 x 103 ng mL-1) for six BPs, and limits of detection varied from 0.14 to 0.73 ng mL-1. Molecular polarity indexes and molecular dynamics simulations revealed why the COF could efficiently recognize and capture BPs. An adsorption mechanism related to the interaction between BP clusters and the COF was discovered. Ecotoxicological assessment of BPs further unraveled the significance of the developed method for the timely tracking of the concentration, distribution, and migration of BPs in environmental media.