Grape (Vitis vinifera L.) phytochemicals and their biochemical protective mechanisms against leading pathologies

被引：20

作者：

Majeed, Usman ^{[1
]}

Shafi, Afshan ^{[2
]}

Majeed, Hamid ^{[3
]}

Akram, Kashif ^{[3
]}

Liu, Xuehua ^{[1
]}

Ye, Jianming ^{[1
]}

Luo, Yane ^{[1
]}

机构：

[1] Northwest Univ, Coll Food Sci & Technol, Xian 710069, Shaanxi, Peoples R China

[2] MNS Univ Agr Multan, Dept Food Sci & Technol, Multan, Pakistan

[3] Cholistan Univ Vet & Anim Sci, Dept Food Sci & Technol, Bahawalpur, Pakistan

来源：

FOOD CHEMISTRY | 2023年 / 405卷

关键词：

Grapes(Vitis viniferaL; Plolyphenols; DNA damage repair; Gene expression modulation; Cardiovascular disease; Health promotion; ANTIOXIDANT DIETARY FIBER; INDUCED OXIDATIVE STRESS; SEED EXTRACT; PHENOLIC-COMPOUNDS; POLYPHENOLIC COMPOUNDS; BIOACTIVE COMPOUNDS; CANCER-CELLS; TUMOR-GROWTH; BLACK-BERRY; IN-VITRO;

D O I：

10.1016/j.foodchem.2022.134762

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The intake of herbal dietary constituents, mostly fruits and vegetables, have been considered well-known to prevent pathologies (degenerative diseases). Consumer awareness/concern regarding a balanced diet has increased their importance in the food chain. Grapes (Vitis vinifera L.), being native to the Mediterranean region, central Europe, and southwest Asia, is a rich source of nutritive (sugar, vitamins, minerals) and non-nutritive/ therapeutic or functional bioactive compounds like quercetin, resveratrol and epigallocatechin-3-gallate that could synergistically help in health promotion. Their disease prevention mechanisms are free radical scavenging, DNA damage repair, and modulation of gene expression in proliferation, metabolism, cell survival, and anti-oxidant defense. This review provides an excellent summary of grape phytochemicals in vivo molecular mech-anisms that lead to health promotion by avoiding oxidative stress-related pathologies like cancer, neurodegeneration, metabolic syndrome, inflammation and cardiovascular diseases. Grape intake-driven dis-ease-preventing mechanism/targets could help to synchronize for an improved efficacy in human pathologies.

引用

页数：14

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