Three-dimensional genome organization in immune cell fate and function

被引：33

作者：

Cuartero, Sergi ^{[1
,2
]}

Stik, Gregoire ^{[3
,4
]}

Stadhouders, Ralph ^{[5
,6
]}

机构：

[1] Josep Carreras Leukaemia Res Inst IJC, Badalona, Spain

[2] Germans Trias & Pujol Res Inst IGTP, Badalona, Spain

[3] Inst Sci & Technol BIST, Ctr Genom Regulat CRC, Barcelona, Spain

[4] Univ Pompeu Fabra UPF, Barcelona, Spain

[5] Erasmus MC, Univ Med Ctr, Dept Pulm Med, Rotterdam, Netherlands

[6] Erasmus MC, Univ Med Ctr, Dept Cell Biol, Rotterdam, Netherlands

来源：

NATURE REVIEWS IMMUNOLOGY | 2023年 / 23卷 / 04期

关键词：

ENHANCER-PROMOTER COMMUNICATION; CCCTC-BINDING FACTOR; PHASE-SEPARATION; TRANSCRIPTION FACTORS; NUCLEAR ARCHITECTURE; COHESIN COMPLEX; DNA-BINDING; T-CELLS; CHROMATIN INTERACTIONS; GENE-EXPRESSION;

D O I：

10.1038/s41577-022-00774-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune cell development and activation demand the precise and coordinated control of transcriptional programmes. Three-dimensional (3D) organization of the genome has emerged as an important regulator of chromatin state, transcriptional activity and cell identity by facilitating or impeding long-range genomic interactions among regulatory elements and genes. Chromatin folding thus enables cell type-specific and stimulus-specific transcriptional responses to extracellular signals, which are essential for the control of immune cell fate, for inflammatory responses and for generating a diverse repertoire of antigen receptor specificities. Here, we review recent findings connecting 3D genome organization to the control of immune cell differentiation and function, and discuss how alterations in genome folding may lead to immune dysfunction and malignancy. Three-dimensional (3D) genome organization has emerged as an important regulator of gene expression and genomic interaction. Here, the authors explain how 3D genome organization impacts immune cell development and function, and discuss how aberrant genome folding can contribute to immune-mediated disease and cancer.

引用

页码：206 / 221

页数：16

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