The protective effect of green tea on diabetes-induced hepato-renal pathological changes: a histological and biochemical study

被引:4
作者
Atia, Tarek [1 ,2 ]
Sakr, Hader, I [3 ,4 ]
Damanhory, Ahmed A. [4 ,5 ]
Moawad, Karim [6 ]
Alsawy, Moustfa [2 ,4 ]
机构
[1] Sattam Bin Abdulaziz Univ, Coll Appl Med Sci Prince, Dept Med Lab Sci, Al Kharj 119422, Saudi Arabia
[2] Al Azhar Univ, Fac Med, Dept Histol & Cytol, Cairo, Egypt
[3] Cairo Univ, Fac Med, Dept Med Physiol, Cairo, Egypt
[4] Batterjee Med Coll, Jeddah, Saudi Arabia
[5] Al Azhar Univ, Fac Med, Dept Biochem, Cairo, Egypt
[6] UCI, Sch Biol Sci, Irvine, CA USA
关键词
Diabetes mellitus; oxidative stress; green tea; glibenclamide; hepato-renal changes; CHRONIC KIDNEY-DISEASE; MELLITUS; GLIBENCLAMIDE; HYPERGLYCEMIA; NEPHROPATHY; ASSOCIATION; PROGRESSION; MANAGEMENT; RATS;
D O I
10.1080/13813455.2020.1806885
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We investigated the protective effect of green tea on diabetic hepato-renal complications. Thirty male Wistar rats were randomly divided into five equal groups: normal control, diabetic control, glibenclamide-treated, green tea-treated, and combined therapy-treated groups; ethical approval number "BERC-014-01-20." After eight weeks, animals were sacrificed by CO(2)euthanasia method, liver and kidney tissues were processed and stained for pathological changes, and blood samples were collected for biochemical analysis. Diabetic rats showed multiple hepato-renal morphological and apoptotic changes associated with significantly increased some biochemical parameters, while serum albumin and HDL decreased significantly compared to normal control (p < .05). Monotherapy can induce significant improvements in pathological and biochemical changes but has not been able to achieve normal patterns. In conclusion, green tea alone has a poor hypoglycaemic effect but can reduce diabetic complications, whereas glibenclamide cannot prevent diabetic complications. The addition of green tea to oral hypoglycaemic therapy has shown a potent synergistic effect.
引用
收藏
页码:168 / 179
页数:12
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