Hippo pathway in cell-cell communication: emerging roles in development and regeneration

被引:4
作者
Nita, Akihiro [1 ]
Moroishi, Toshiro [1 ,2 ]
机构
[1] Kumamoto Univ, Fac Life Sci, Dept Mol & Med Pharmacol, 1-1-1 Honjo, Kumamoto 8608556, Japan
[2] Kumamoto Univ, Fac Life Sci, Ctr Metab Regulat Hlth Aging, Kumamoto, Japan
基金
日本学术振兴会; 日本科学技术振兴机构;
关键词
The Hippo pathway; Cell-cell communication; Development; Regeneration; Heterogeneity; ORGAN SIZE CONTROL; TUMOR-SUPPRESSOR PATHWAY; SIGNALING PATHWAY; PROLIFERATION ARREST; PROMOTES APOPTOSIS; TISSUE HOMEOSTASIS; TEAD/TEF FAMILY; CYCLE EXIT; YAP; DROSOPHILA;
D O I
10.1186/s41232-024-00331-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The Hippo pathway is a central regulator of tissue growth that has been widely studied in mammalian organ development, regeneration, and cancer biology. Although previous studies have convincingly revealed its cell-autonomous functions in controlling cell fate, such as cell proliferation, survival, and differentiation, accumulating evidence in recent years has revealed its non-cell-autonomous functions. This pathway regulates cell-cell communication through direct interactions, soluble factors, extracellular vesicles, and the extracellular matrix, providing a range of options for controlling diverse biological processes. Consequently, the Hippo pathway not only dictates the fate of individual cells but also triggers multicellular responses involving both tissue-resident cells and infiltrating immune cells. Here, we have highlighted the recent understanding of the molecular mechanisms by which the Hippo pathway controls cell-cell communication and discuss its importance in tissue homeostasis, especially in development and regeneration.
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页数:13
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