Mosaic loss of chromosome Y and cardiovascular disease

被引：2

作者：

Sano, Soichi ^{[1
]}

Walsh, Kenneth ^{[2
]}

机构：

[1] Natl Cerebral & Cardiovasc Ctr, Lab Cardiovasc Mosaicism, Suita, Japan

[2] Univ Virginia, Sch Med, Hematovasc Biol Ctr, Robert M Berne Cardiovasc Res Ctr, Charlottesville, VA 22903 USA

来源：

NATURE REVIEWS CARDIOLOGY | 2024年 / 21卷 / 03期

关键词：

BLOOD;

D O I：

10.1038/s41569-023-00976-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mosaic loss of chromosome Y (mLOY) refers to the condition in male individuals in which a detectable fraction of cells lose the Y chromosome. Prevalent in haematopoietic cells, this common somatic mutation is associated with decreased longevity and an increased risk of age-related diseases, including cardiovascular disease. Haematopoietic mLOY provides further insight into the sex-specific disparities that exist in disease susceptibility.

引用

页码：151 / 152

页数：2

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