Changes in brain structure in subjects with resistance to thyroid hormone due to THRB mutations

被引：5

作者：

Rogge, Berenike ^{[1
]}

Heldmann, Marcus ^{[1
,2
]}

Chatterjee, Krishna ^{[3
]}

Moran, Carla ^{[4
,5
,6
]}

Goettlich, Martin ^{[2
]}

Uter, Jan ^{[1
]}

Wagner-Altendorf, Tobias A. A. ^{[1
]}

Steinhardt, Julia ^{[1
]}

Brabant, Georg ^{[7
]}

Muente, Thomas F. F. ^{[1
,2
]}

Cirkel, Anna ^{[1
]}

机构：

[1] Univ Lubeck, Dept Neurol, Ratzeburger Allee 160, D-23538 Lubeck, Germany

[2] Univ Lubeck, Dept Psychol 2, Lubeck, Germany

[3] Univ Cambridge, Wellcome MRC Inst Metab Sci, Cambridge, England

[4] Beacon Hosp, Dublin, Ireland

[5] St Vincents Univ Hosp, Dublin, Ireland

[6] Univ Coll Dublin, Sch Med, Dublin, Ireland

[7] Univ Lubeck, Dept Internal Med 1, Lubeck, Germany

来源：

THYROID RESEARCH | 2023年 / 16卷 / 01期

基金：

英国惠康基金;

关键词：

Resistance to thyroid hormone; voxel based morphometry; Diffusion tensor imaging; Thyroid hormone receptor beta; DEFICIT-HYPERACTIVITY DISORDER; COGNITIVE FUNCTIONS; CORTICAL THICKNESS; CHILDREN; MORPHOMETRY; THYROTOXICOSIS; ABNORMALITIES; ALGORITHM; MATTER; ADHD;

D O I：

10.1186/s13044-023-00176-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundBeing critical for brain development and neurocognitive function thyroid hormones may have an effect on behaviour and brain structure. Our exploratory study aimed to delineate the influence of mutations in the thyroid hormone receptor (TR) ss gene on brain structure.MethodsHigh-resolution 3D T1-weighted images were acquired in 21 patients with a resistance to thyroid hormone ss (RTHss) in comparison to 21 healthy matched-controls. Changes in grey and white matter, as well as cortical thickness were evaluated using voxel-based morphometry (VBM) and diffusion tensor imaging (DTI).ResultsRTHss patients showed elevated circulating fT4 & fT3 with normal TSH concentrations, whereas controls showed normal thyroid hormone levels. RTHss patients revealed significantly higher scores in a self-rating questionnaire for attention deficit hyperactivity disorder (ADHD). Imaging revealed alterations of the corticospinal tract, increased cortical thickness in bilateral superior parietal cortex and decreased grey matter volume in bilateral inferior temporal cortex and thalamus.ConclusionRTHb patients exhibited structural changes in multiple brain areas. Whether these structural changes are causally linked to the abnormal behavioral profile of RTHss which is similar to ADHD, remains to be determined.

引用

页数：10

共 51 条

[1] Divergent roles for thyroid hormone receptor β isoforms in the endocrine axis and auditory system [J].

Abel, ED ;

Boers, ME ;

Pazos-Moura, C ;

Moura, E ;

Kaulbach, H ;

Zakaria, M ;

Lowell, B ;

Radovick, S ;

Liberman, MC ;

Wondisford, F .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (03) :291-300

[2] Unified segmentation [J].

Ashburner, J ;

Friston, KJ .

NEUROIMAGE, 2005, 26 (03) :839-851

[3] The tract terminations in the temporal lobe: Their location and associated functions [J].

Bajada, Claude J. ;

Haroon, Hamied A. ;

Azadbakht, Hojjatollah ;

Parker, Geoff J. M. ;

Ralph, Matthew A. Lambon ;

Cloutman, Lauren L. .

CORTEX, 2017, 97 :277-290

[4] Thyroid hormone receptors in brain development and function [J].

Bernal, Juan .

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM, 2007, 3 (03) :249-259

[5] Inhibition-related modulation of salience and frontoparietal networks predicts cognitive control ability and inattention symptoms in children with ADHD [J].

Cai, Weidong ;

Griffiths, Kristi ;

Korgaonkar, Mayuresh S. ;

Williams, Leanne Maree ;

Menon, Vinod .

MOLECULAR PSYCHIATRY, 2021, 26 (08) :4016-4025

[6] Retinal Photoreceptor Functions Are Compromised in Patients With Resistance to Thyroid Hormone Syndrome (RTHβ) [J].

Campi, Irene ;

Cammarata, Gabriella ;

Marzoli, Stefania Bianchi ;

Beck-Peccoz, Paolo ;

Santarsiero, Diletta ;

Dazzi, Davide ;

de Castello, Alessandra Bottari ;

Taroni, Elena Giuliana ;

Viola, Francesco ;

Mian, Caterina ;

Watutantrige-Fernando, Sara ;

Pelusi, Carla ;

Muzza, Marina ;

Maffini, Maria Antonia ;

Persani, Luca .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2017, 102 (07) :2620-2627

[7] Do children with congenital hypothyroidism exhibit abnormal cortical morphology? [J].

Clairman, Hayyah ;

Skocic, Jovanka ;

Lischinsky, Julieta E. ;

Rovet, Joanne .

PEDIATRIC RESEARCH, 2015, 78 (03) :286-297

[8] The Organization and Operation of Inferior Temporal Cortex [J].

Conway, Bevil R. .

ANNUAL REVIEW OF VISION SCIENCE, VOL 4, 2018, 4 :381-402

[9] Cortical thickness and central surface estimation [J].

Dahnke, Robert ;

Yotter, Rachel Aine ;

Gaser, Christian .

NEUROIMAGE, 2013, 65 :336-348

[10] An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest [J].

Desikan, Rahul S. ;

Segonne, Florent ;

Fischl, Bruce ;

Quinn, Brian T. ;

Dickerson, Bradford C. ;

Blacker, Deborah ;

Buckner, Randy L. ;

Dale, Anders M. ;

Maguire, R. Paul ;

Hyman, Bradley T. ;

Albert, Marilyn S. ;

Killiany, Ronald J. .

NEUROIMAGE, 2006, 31 (03) :968-980

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