Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls

被引：29

作者：

Biria, Marjan ^{[1
,2
]}

Banca, Paula ^{[1
,2
]}

Healy, Mairead P. ^{[1
,2
]}

Keser, Engin ^{[1
]}

Sawiak, Stephen J. ^{[2
,3
]}

Rodgers, Christopher T. ^{[4
]}

Rua, Catarina ^{[4
,5
,6
]}

de Souza, Ana Maria Frota Lisboa Pereira ^{[1
,2
]}

Marzuki, Aleya A. ^{[1
,2
,7
]}

Sule, Akeem ^{[8
]}

Ersche, Karen D. ^{[8
,9
,10
]}

Robbins, Trevor W. ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, England

[2] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England

[3] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3EL, England

[4] Univ Cambridge, Wolfson Brain Imaging Ctr, Dept Clin Neurosci, Cambridge CB2 0QQ, England

[5] Univ Cambridge, Dept Clin Neurosci, Cambridge, England

[6] Univ Cambridge, Cambridge Univ Hosp NHS Trust, Cambridge, England

[7] Sunway Univ, Sch Med & Life Sci, Dept Psychol, Petaling Jaya, Malaysia

[8] Univ Cambridge, Sch Clin Med, Dept Psychiat, Cambridge, England

[9] Univ Med Ctr Hamburg Eppendorf, Dept Syst Neurosci, Hamburg, Germany

[10] Heidelberg Univ, Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, Heidelberg, Germany

来源：

NATURE COMMUNICATIONS | 2023年 / 14卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

MAGNETIC-RESONANCE-SPECTROSCOPY; ANTERIOR CINGULATE CORTEX; GAMMA-AMINOBUTYRIC-ACID; MEDIAL FRONTAL-CORTEX; METABOLITE CONCENTRATIONS; RESPONSE-INHIBITION; N-ACETYLASPARTATE; PREFRONTAL CORTEX; BRAIN SYSTEMS; SHORT-ECHO;

D O I：

10.1038/s41467-023-38695-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There has been little analysis of neurochemical correlates of compulsive behaviour to illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance spectroscopy (H-1-MRS) to assess the balance of excitatory and inhibitory neurotransmission by measuring glutamate and GABA levels in anterior cingulate cortex (ACC) and supplementary motor area (SMA) of healthy volunteers and participants with Obsessive-Compulsive Disorder (OCD). Within the SMA, trait and clinical measures of compulsive behaviour are related to glutamate levels, whereas a behavioural index of habitual control correlates with the glutamate:GABA ratio. Participants with OCD also show the latter relationship in the ACC while exhibiting elevated glutamate and lower GABA levels in that region. This study highlights SMA mechanisms of habitual control relevant to compulsive behaviour, common to the healthy sub-clinical and OCD populations. The results also demonstrate additional involvement of anterior cingulate in the balance between goal-directed and habitual responding in OCD. The neurochemical basis of compulsive behaviour is not well understood. Here, the authors show that levels of glutamate and GABA in the supplementary motor area and anterior cingulate cortex relate to compulsive behaviour in healthy controls and individuals with OCD.

引用

页数：13

共 101 条

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