Towards Automated and High-Throughput Quantitative Sizing and Isotopic Analysis of Nanoparticles via Single Particle-ICP-TOF-MS

被引:8
|
作者
Manard, Benjamin T. T. [1 ]
Bradley, Veronica C. C. [1 ]
Quarles, C. Derrick [2 ]
Hendriks, Lyndsey [3 ]
Dunlap, Daniel R. R. [1 ]
Hexel, Cole R. R. [1 ]
Sullivan, Patrick [2 ]
Andrews, Hunter B. B. [4 ]
机构
[1] Oak Ridge Natl Lab, Chem Sci Div, Oak Ridge, TN 37831 USA
[2] Elemental Sci Inc, Omaha, NE 68122 USA
[3] TOFWERK AG, CH-3645 Thun, Switzerland
[4] Oak Ridge Natl Lab, Radioisotope Sci & Technol Div, Oak Ridge, TN 37831 USA
关键词
nanoparticles; automated; high throughput; single particle; ICP-TOF-MS; SP-ICP-MS; PLASMA-MASS SPECTROMETRY; INTRODUCTION SYSTEM; SIZE;
D O I
10.3390/nano13081322
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The work described herein assesses the ability to characterize gold nanoparticles (Au NPs) of 50 and 100 nm, as well as 60 nm silver shelled gold core nanospheres (Au/Ag NPs), for their mass, respective size, and isotopic composition in an automated and unattended fashion. Here, an innovative autosampler was employed to mix and transport the blanks, standards, and samples into a high-efficiency single particle (SP) introduction system for subsequent analysis by inductively coupled plasma-time of flight-mass spectrometry (ICP-TOF-MS). Optimized NP transport efficiency into the ICP-TOF-MS was determined to be >80%. This combination, SP-ICP-TOF-MS, allowed for high-throughput sample analysis. Specifically, 50 total samples (including blanks/standards) were analyzed over 8 h, to provide an accurate characterization of the NPs. This methodology was implemented over the course of 5 days to assess its long-term reproducibility. Impressively, the in-run and day-to-day variation of sample transport is assessed to be 3.54 and 9.52% relative standard deviation (%RSD), respectively. The determination of Au NP size and concentration was of <5% relative difference from the certified values over these time periods. Isotopic characterization of the Ag-107/Ag-109 particles (n = 132,630) over the course of the measurements was determined to be 1.0788 +/- 0.0030 with high accuracy (0.23% relative difference) when compared to the multi-collector-ICP-MS determination.
引用
收藏
页数:12
相关论文
共 50 条
  • [21] Machine learning: our future spotlight into single-particle ICP-ToF-MS analysis
    Holbrook, Timothy Ronald
    Gallot-Duval, Doriane
    Reemtsma, Thorsten
    Wagner, Stephan
    JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, 2021, 36 (12) : 2684 - 2694
  • [22] High-throughput analysis of sulfatides in cerebrospinal fluid using automated extraction and UPLC-MS/MS
    Blomqvist, Maria
    Boren, Jan
    Zetterberg, Henrik
    Blennow, Kaj
    Mansson, Jan-Eric
    Stahlman, Marcus
    JOURNAL OF LIPID RESEARCH, 2017, 58 (07) : 1482 - 1489
  • [23] High-throughput mercury speciation analysis of breast milk using HPLC-ICP-MS
    Iwai, Kenta
    Iwai-Shimada, Miyuki
    Tatsuta, Nozomi
    Kobayashi, Yayoi
    Asato, Kaname
    Nishimoto, Mitsuo
    Nakai, Kunihiko
    Nakayama, Shoji F.
    MICROCHEMICAL JOURNAL, 2025, 211
  • [24] Development and validation of single particle ICP-MS for sizing and quantitative determination of nano-silver in chicken meat
    Peters, Ruud J. B.
    Rivera, Zahira Herrera
    van Bemmel, Greet
    Marvin, Hans J. P.
    Weigel, Stefan
    Bouwmeester, Hans
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2014, 406 (16) : 3875 - 3885
  • [25] Overcoming challenges in single particle ICP-MS analysis of redox active nanoparticles
    Liu, Jingyu
    Murphy, Karen
    Winchester, Michael
    Hackley, Vincent
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [26] Development and validation of single particle ICP-MS for sizing and quantitative determination of nano-silver in chicken meat
    Ruud J. B. Peters
    Zahira Herrera Rivera
    Greet van Bemmel
    Hans J. P. Marvin
    Stefan Weigel
    Hans Bouwmeester
    Analytical and Bioanalytical Chemistry, 2014, 406 : 3875 - 3885
  • [27] Sample preparation for the analysis of nanoparticles in natural waters by single particle ICP-MS
    Jreije, Ibrahim
    Hadioui, Madjid
    Wilkinson, Kevin J.
    TALANTA, 2022, 238
  • [28] Negative Magnetophoresis Focusing Microchips Online-Coupled with ICP-MS for High-Throughput Single-Cell Analysis
    Chen, Zhenna
    Chen, Beibei
    He, Man
    Hu, Bin
    ANALYTICAL CHEMISTRY, 2022, 94 (18) : 6649 - 6656
  • [29] MPep MALDI Chips for high-sensitivity and high-throughput peptide analysis by MALDI-TOF MS
    Holger Röhl
    Sven Goethel
    Karsten Reihs
    Nature Methods, 2005, 2 (6) : 478 - 478
  • [30] DBS direct elution: optimizing performance in high-throughput quantitative LC-MS/MS analysis
    Abu-Rabie, Paul
    Spooner, Neil
    Chowdhry, Babur Z.
    Pullen, Frank S.
    BIOANALYSIS, 2015, 7 (16) : 2003 - 2017