Susceptibility to hepatitis B virus infection in adults living in Spain

被引：7

作者：

Soriano, Vicente ^{[1
]}

Aguilera, Antonio ^{[2
,3
]}

Benito, Rafael ^{[4
,5
]}

Gonzalez-Diez, Rocio ^{[6
]}

Miro, Elisenda ^{[7
]}

Liendo, Paloma ^{[8
]}

Rodriguez-Diaz, Juan Carlos ^{[9
]}

Cabezas, Teresa ^{[10
]}

Richart, Alberto ^{[6
]}

Ramos, Jose Manuel ^{[9
]}

Barea, Luisa ^{[6
]}

Alvarez, Carmen ^{[1
]}

Trevino, Ana ^{[1
]}

Gomez-Gallego, Felix ^{[1
]}

Corral, Octavio ^{[1
]}

de Mendoza, Carmen ^{[11
]}

机构：

[1] Univ Int Rioja, UNIR, Madrid, Spain

[2] Hosp Clin Univ Santiago, Santiago De Compostela, Spain

[3] USC, GI-1209, Santiago De Compostela, Spain

[4] Hosp Univ Lozano Blesa, Zaragoza, Spain

[5] Univ Zaragoza, Zaragoza, Spain

[6] Ctr Transfus Comun Madrid, Madrid, Spain

[7] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[8] Hosp Gen Basurto, Bilbao, Spain

[9] Hosp Gen Univ Dr Balmis, Alicante, Spain

[10] Hosp Torrecardenas, Almeria, Spain

[11] Puerta Hierro Univ Hosp & Res Inst, Majadahonda, Spain

来源：

LIVER INTERNATIONAL | 2023年 / 43卷 / 05期

关键词：

antibody waning; diagnosis; hepatitis B; prevention; public health; vaccine; UNITED-STATES; ADVISORY-COMMITTEE; VACCINE; IMMUNIZATION; RECOMMENDATIONS; CHALLENGE; SCHEDULE; ANTIBODY; IMMUNITY;

D O I：

10.1111/liv.15548

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BackgroundA protective hepatitis B virus (HBV) vaccine has been available for four decades. Universal HBV vaccination of infants is recommended by the WHO since the 1990s. Furthermore, HBV immunization is advised for all adults with high-risk behaviours and no seroprotection. However, HBV vaccine coverage remains globally suboptimal. The advent of new more efficacious trivalent HBV vaccines has renewed the interest in HBV vaccination. At present, the extent of current HBV susceptibility in adults remains unknown in Spain. MethodsHBV serological markers were assessed on a large and representative sample of adults in Spain, including blood donors and individuals belonging to high-risk groups. Serum HBsAg, anti-HBc and anti-HBs were tested in specimens collected during the last couple of years. ResultsFrom 13 859 consecutive adults tested at seven cities across the Spanish geography, overall 166 (1.2%) had positive HBsAg. Past HBV infection was recognized in 14% and prior vaccine immunization in 24%. Unexpectedly, 37% of blood donors and 63% of persons belonging to high-risk groups had no serum HBV markers and therefore were potentially HBV susceptible. ConclusionRoughly 60% of adults living in Spain seem to be HBV susceptible. Waning immunity might be more common than expected. Hence, HBV serological testing should be performed at least once in all adults regardless of risk exposures. HBV vaccine full courses or boosters should be administered to all adults lacking serological evidence of HBV protection.

引用

页码：1015 / 1020

页数：6