A review of highly sensitive electrochemical genosensors for microRNA detection: A novel diagnostic platform for neurodegenerative diseases diagnostics

被引:8
作者
Sanavi, Mehrnoosh Azimi [1 ]
Mahdavian, Farzaneh [2 ]
Dorosti, Nafiseh [3 ]
Karami, Neda [4 ]
Karami, Sajedeh [5 ]
Khatami, Seyyed Hossein [6 ]
Vakili, Omid [7 ]
Taheri-Anganeh, Mortaza [8 ]
Karima, Saeed [6 ]
Movahedpour, Ahmad [9 ]
机构
[1] Mazandaran Univ Med Sci, Fac Med, Mol & Cell Biol Res Ctr, Dept Biochem & Genet, Sari, Iran
[2] Mazandaran Univ Med Sci, Fac Adv Technol Med, Dept Med Biotechnol, Sari, Iran
[3] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Med Nanotechnol, Sari, Iran
[4] TU Wien, Inst Solid State Elect, Vienna, Austria
[5] Shiraz Univ, Dept Chem, Shiraz, Iran
[6] Shahid Beheshti Univ Med Sci, Sch Med, Dept Clin Biochem, Tehran, Iran
[7] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan, Iran
[8] Urmia Univ Med Sci, Cellular & Mol Med Inst, Cellular & Mol Res Ctr, Orumiyeh, Iran
[9] Behbahan Fac Med Sci, Behbahan, Iran
关键词
diagnosis; electrochemical biosensor; microRNA; miRNA; neurodegenerative; GRAPHENE OXIDE; IMPEDIMETRIC DETECTION; ELECTRODES; BIOMARKERS; BIOSENSORS; BIOGENESIS; MARKERS; STROKE; MIRNA;
D O I
10.1002/bab.2419
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The significant role of microRNAs in regulating gene expression and in disease tracking has handed the possibility of robust and accurate diagnosis of various diseases. Measurement of these biomarkers has also had a significant impact on the preparation of natural samples. Discovery of miRNAs is a major challenge due to their small size in the real sample and their short length, which is generally measured by complex and expensive methods. Electrochemical nanobiosensors have made significant progress in this field. Due to the delicate nature of nerve tissue repair and the significance of rapid-fire feature of neurodegenerative conditions, these biosensors can be reliably promising. This review presents advances in the field of neurodegenerative diseases diagnostics. At the same time, there are still numerous openings in this field that are a bright prospect for researchers in the rapid-fire opinion of neurological diseases and indeed nerve tissue repair.
引用
收藏
页码:1044 / 1056
页数:13
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