COVID-19 susceptibility and clinical outcomes in inflammatory bowel disease: An updated systematic review and meta-analysis

被引:8
作者
Lee, Min Ho [1 ]
Li, Han Jacob [2 ]
Wasuwanich, Paul [2 ]
Kim, Sung Eun [1 ]
Kim, Jong Yeob [1 ]
Jeong, Gwang Hun [3 ]
Park, Seoyeon [1 ]
Yang, Jae Won [4 ]
Kim, Min Seo [5 ]
Yon, Dong Keon [6 ,7 ]
Lee, Seung Won [8 ]
Koyanagi, Ai [9 ,10 ]
Jacob, Louis [9 ,11 ,12 ]
Kim, Eun-Young [13 ]
Cheon, Jae Hee [14 ]
Shin, Jae Il [15 ]
Smith, Lee [16 ]
机构
[1] Yonsei Univ, Coll Med, Seoul, South Korea
[2] Univ Florida, Coll Med, Gainesville, FL USA
[3] Gyeongsang Natl Univ, Coll Med, Jinju, South Korea
[4] Yonsei Univ, Dept Nephrol, Wonju Coll Med, Wonju, South Korea
[5] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Dept Digital Hlth, Seoul, South Korea
[6] Kyung Hee Univ, Dept Pediat, Coll Med, Seoul, South Korea
[7] Kyung Hee Univ, Ctr Digital Hlth, Med Sci Res Inst, Med Ctr, Seoul, South Korea
[8] Sungkyunkwan Univ, Dept Precis Med, Sch Med, Suwon, South Korea
[9] ISCIII, Res & Dev Unit, CIBERSAM, Parc Sanitari St Joan de Deu, Barcelona, Spain
[10] ICREA, Barcelona, Spain
[11] Univ Versailles St Quentin En Yvelines, Fac Med, Montigny Le Bretonneux, France
[12] Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
[13] Chung Ang Univ, Coll Pharm, Dept Hlth Social & Clin Pharm, Evidence Based & Clin Res Lab, Seoul, South Korea
[14] Yonsei Univ, Severance Hosp, Dept Internal Med, Coll Med, Seoul, South Korea
[15] Yonsei Univ, Dept Pediat, Coll Med, Yonsei Ro 50,CPO Box 8044, Seoul 03722, South Korea
[16] Anglia Ruskin Univ, Cambridge Ctr Sport & Exercise Sci, Cambridge, England
关键词
COVID-19; Crohn's disease; inflammatory bowel disease; meta-analysis; ulcerative colitis; CORONAVIRUS; INFECTION; ACE2; PREVALENCE; EXPRESSION; SEVERITY; RECEPTOR; QUALITY; TMPRSS2; AGE;
D O I
10.1002/rmv.2414
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The susceptibility, risk factors, and prognosis of COVID-19 in patients with inflammatory bowel disease (IBD) remain unknown. Thus, our study aims to assess the prevalence and clinical outcomes of COVID-19 in IBD. We searched PubMed, EMBASE, and medRxiv from 2019 to 1 June 2022 for cohort and case-control studies comparing the prevalence and clinical outcomes of COVID-19 in patients with IBD and in the general population. We also compared the outcomes of patients receiving and not receiving 5-aminosalicylates (ASA), tumour necrosis factor antagonists, biologics, systemic corticosteroids, or immunomodulators for IBD. Thirty five studies were eligible for our analysis. Pooled odds ratio of COVID-19-related hospitalisation, intensive care unit (ICU) admission, or death in IBD compared to in non-IBD were 0.58 (95% confidence interval (CI) = 0.28-1.18), 1.09 (95% CI = 0.27-4.47), and 0.67 (95% CI = 0.32-1.42), respectively. Inflammatory bowel disease was not associated with increased hospitalisation, ICU admission, or death. Susceptibility to COVID-19 did not increase with any drugs for IBD. Hospitalisation, ICU admission, and death were more likely with 5-ASA and corticosteroid use. COVID-19-related hospitalisation (Odds Ratio (OR): 0.53; 95% CI = 0.38-0.74) and death (OR: 0.13; 95% CI = 0.13-0.70) were less likely with Crohn's disease than ulcerative colitis (UC). In conclusion, IBD does not increase the mortality and morbidity of COVID-19. However, physicians should be aware that additional monitoring is needed in UC patients or in patients taking 5-ASA or systemic corticosteroids.
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页数:15
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