Understanding and countering opioid-induced respiratory depression

被引：58

作者：

Bateman, Jordan T. ^{[1
]}

Saunders, Sandy E. ^{[1
]}

Levitt, Erica S. ^{[1
,2
]}

机构：

[1] Univ Florida, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA

[2] Univ Florida, Breathing Res & Therapeut Ctr, Gainesville, FL 32610 USA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2023年 / 180卷 / 07期

基金：

美国国家卫生研究院;

关键词：

addiction; brainstem; control of breathing; electrophysiology; mu opioid receptor; opioids; respiratory pharmacology; INDUCED VENTILATORY DEPRESSION; PRE-BOTZINGER COMPLEX; RAT BRAIN-STEM; KOLLIKER-FUSE NEURONS; PREBOTZINGER COMPLEX; PARABRACHIAL NUCLEUS; CONCISE GUIDE; SPINAL-CORD; SELECTIVE; 5-HT1A-R-AGONIST; INTRAVENOUS REMIFENTANIL;

D O I：

10.1111/bph.15580

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Respiratory depression is the proximal cause of death in opioid overdose, yet the mechanisms underlying this potentially fatal outcome are not well understood. The goal of this review is to provide a comprehensive understanding of the pharmacological mechanisms of opioid-induced respiratory depression, which could lead to improved therapeutic options to counter opioid overdose, as well as other detrimental effects of opioids on breathing. The development of tolerance in the respiratory system is also discussed, as are differences in the degree of respiratory depression caused by various opioid agonists. Finally, potential future therapeutic agents aimed at reversing or avoiding opioid-induced respiratory depression through non-opioid receptor targets are in development and could provide certain advantages over naloxone. By providing an overview of mechanisms and effects of opioids in the respiratory network, this review will benefit future research on countering opioid-induced respiratory depression.

引用

页码：813 / 828

页数：16

共 154 条

[1] Abdominal expiratory activity in the rat brainstem-spinal cord in situ: patterns, origins and implications for respiratory rhythm generation [J].

Abdala, A. P. L. ;

Rybak, I. A. ;

Smith, J. C. ;

Paton, J. F. R. .

JOURNAL OF PHYSIOLOGY-LONDON, 2009, 587 (14) :3539-3559

[2] Deficiency of GABAergic synaptic inhibition in the Kolliker-Fuse area underlies respiratory dysrhythmia in a mouse model of Rett syndrome [J].

Abdala, Ana Paula ;

Toward, Marie A. ;

Dutschmann, Mathias ;

Bissonnette, Johnm. ;

Paton, Julian F. R. .

JOURNAL OF PHYSIOLOGY-LONDON, 2016, 594 (01) :223-237

[3]

Aicher SA, 2000, J COMP NEUROL, V422, P181, DOI 10.1002/(SICI)1096-9861(20000626)422:2<181::AID-CNE3>3.0.CO

[4]

2-G

[5]

Alexander SPH, 2019, BRIT J PHARMACOL, V176, pS297, DOI [10.1111/bph.14752, 10.1111/bph.14749]

[6] THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors [J].

Alexander, Stephen P. H. ;

Christopoulos, Arthur ;

Davenport, Anthony P. ;

Kelly, Eamonn ;

Mathie, Alistair ;

Peters, John A. ;

Veale, Emma L. ;

Armstrong, Jane F. ;

Faccenda, Elena ;

Harding, Simon D. ;

Pawson, Adam J. ;

Sharman, Joanna L. ;

Southan, Christopher ;

Davies, Jamie A. ;

Arumugam, Thiruma V. ;

Bennett, Andrew ;

Sjogren, Benita ;

Sobey, Christopher ;

Wong, Szu Shen ;

Abbracchio, Maria P. ;

Alexander, Wayne ;

Al-hosaini, Khaled ;

Back, Magnus ;

Beaulieu, Jean-Martin ;

Bernstein, Kenneth E. ;

Bettler, Bernhard ;

Birdsall, Nigel J. M. ;

Blaho, Victoria ;

Bousquet, Corinne ;

Brauner-Osborne, Hans ;

Burnstock, Geoffrey ;

Calo, Girolamo ;

Castano, Justo P. ;

Catt, Kevin J. ;

Ceruti, Stefania ;

Chazot, Paul ;

Chiang, Nan ;

Chun, Jerold ;

Cianciulli, Antonia ;

Clapp, Lucie H. ;

Couture, Rejean ;

Csaba, Zsolt ;

Dent, Gordon ;

Singh, Khuraijam Dhanachandra ;

Douglas, Steven D. ;

Dournaud, Pascal ;

Eguchi, Satoru ;

Escher, Emanuel ;

Filardo, Edward ;

Fong, Tung M. .

BRITISH JOURNAL OF PHARMACOLOGY, 2019, 176 :S21-S141

[7] Tolerance to Opioid-Induced Respiratory Depression in Chronic High-Dose Opioid Users: A Model-Based Comparison With Opioid-Naive Individuals [J].

Algera, Marijke Hyke ;

Olofsen, Erik ;

Moss, Laurence ;

Dobbins, Robert L. ;

Niesters, Marieke ;

van Velzen, Monique ;

Groeneveld, Geert Jan ;

Heuberger, Jules ;

Laffont, Celine M. ;

Dahan, Albert .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2021, 109 (03) :637-645

[8] A novel excitatory network for the control of breathing [J].

Anderson, Tatiana M. ;

Garcia, Alfredo J., III ;

Baertsch, Nathan A. ;

Pollak, Julia ;

Bloom, Jacob C. ;

Wei, Aguan D. ;

Rai, Karan G. ;

Ramirez, Jan-Marino .

NATURE, 2016, 536 (7614) :76-+

[9] Methadone maintenance patients are cross-tolerant to the antinociceptive effects of very high plasma morphine concentrations [J].

Athanasos, P ;

Smith, CS ;

White, JM ;

Somogyi, AA ;

Bochner, F ;

Ling, W .

PAIN, 2006, 120 (03) :267-275

[10] Bilateral carotid sinus nerve transection exacerbates morphine-induced respiratory depression [J].

Baby, Santhosh M. ;

Gruber, Ryan B. ;

Young, Alex P. ;

MacFarlane, Peter M. ;

Teppema, Luc J. ;

Lewis, Stephen J. .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2018, 834 :17-29

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