Bacterial antigens unleash tumor-targeting immunity

被引:0
|
作者
Boeck, Nina [1 ,2 ]
Trajanoski, Zlatko [2 ]
Galluzzi, Lorenzo [1 ,3 ,4 ]
机构
[1] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY 10065 USA
[2] Med Univ Innsbruck, Inst Bioinformat, Bioctr, Innsbruck, Austria
[3] Sandra & Edward Meyer Canc Ctr, New York, NY 10065 USA
[4] Caryl & Israel Englander Inst Precis Med, New York, NY 10065 USA
基金
欧洲研究理事会;
关键词
D O I
10.1016/j.chom.2023.11.001
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The composition of the gut microbiome has been shown to influence disease outcome in patients with colorectal cancer (CRC). In a recent Nature Biotechnology article, Wang et al. demonstrate that killing CRC -associated bacteria with a liposomal antibiotic elicits CRC-targeting immune responses of therapeutic relevance as a consequence of epitope mimicry.
引用
收藏
页码:1945 / 1947
页数:3
相关论文
共 50 条
  • [1] Tumor-targeting bacterial therapy: A potential treatment for oral cancer
    Liu, Sai
    Xu, Xiaoping
    Zeng, Xin
    Li, Longjiang
    Chen, Qianming
    Li, Jing
    ONCOLOGY LETTERS, 2014, 8 (06) : 2359 - 2366
  • [2] Tumor-targeting oncolytic virus elicits potent immunotherapeutic vaccine responses to tumor antigens
    Luo, Yong
    Lin, Chaolong
    Zou, Yidi
    Ju, Fei
    Ren, Wenfeng
    Lin, Yanhua
    Wang, Yale
    Huang, Xiaoxuan
    Liu, Huiling
    Yu, Zeng
    Liu, Pingguo
    Tan, Guowei
    Yuan, Quan
    Zhang, Jun
    Huang, Chenghao
    Xia, Ningshao
    ONCOIMMUNOLOGY, 2020, 9 (01):
  • [3] Tumor-Targeting Theranostic Polymers
    Wei, Ying
    Wang, Mingfeng
    LANGMUIR, 2025, 41 (12) : 7928 - 7945
  • [4] Tracking Down Tumor-Targeting Bacteria
    不详
    CANCER DISCOVERY, 2012, 2 (03)
  • [5] Novel Treatment Strategies for Cancer and Their Tumor-targeting Approaches Using Antibodies Against Tumor-associated Antigens
    Kuroki, Masahide
    Shirasu, Naoto
    ANTICANCER RESEARCH, 2014, 34 (08) : 4481 - 4488
  • [6] Methods for the development of tumor-targeting bacteria
    Hoffman, Robert M.
    Zhao, Ming
    EXPERT OPINION ON DRUG DISCOVERY, 2014, 9 (07) : 741 - 750
  • [7] The evolution of antibodies into versatile tumor-targeting
    Lin, MZ
    Teitell, MA
    Schiller, GJ
    CLINICAL CANCER RESEARCH, 2005, 11 (01) : 129 - 138
  • [8] Pancreatic Tumor-Targeting Stemsome Therapeutics
    Park, Jun-Young
    Park, Jun Young
    Jeong, Yong-Gyu
    Park, Joo-Hwan
    Park, Yeon Ho
    Kim, Sang-Hyun
    Khang, Dongwoo
    ADVANCED MATERIALS, 2023, 35 (30)
  • [9] Tumor-targeting of viral vectors for cancer gene therapy by using antibodies or their genes against tumor-associated antigens
    Kuroki, M
    Kuroki, M
    Shibaguchi, H
    Hachimine, K
    Kinugasa, T
    Badran, A
    ANTICANCER RESEARCH, 2004, 24 (5C) : 3373 - 3377
  • [10] Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium
    Zhao, M
    Yang, M
    Li, XM
    Jiang, P
    Baranov, E
    Li, SK
    Xu, MX
    Penman, S
    Hoffman, RM
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (03) : 755 - 760