Metabolomic-Based Approaches for Endometrial Cancer Diagnosis and Prognosis: A Review

Simple Summary Endometrial cancer, the most common gynecological malignancy in developed countries, poses a growing challenge with rising incidence and mortality rates. This review explores how metabolomic technology can offer valuable insights into the molecular aspects of the disease. By identifying new possible metabolite biomarkers, it has the potential to improve the accuracy of diagnosis, prognosis, and monitoring, thereby revolutionizing the management of endometrial cancer.Abstract Endometrial cancer, the most prevalent gynecological malignancy in developed countries, is experiencing a sustained rise in both its incidence and mortality rates, primarily attributed to extended life expectancy and lifestyle factors. Currently, the absence of precise diagnostic tools hampers the effective management of the expanding population of women at risk of developing this disease. Furthermore, patients diagnosed with endometrial cancer require precise risk stratification to align with optimal treatment planning. Metabolomics technology offers a unique insight into the molecular landscape of endometrial cancer, providing a promising approach to address these unmet needs. This comprehensive literature review initiates with an overview of metabolomic technologies and their intrinsic workflow components, aiming to establish a fundamental understanding for the readers. Subsequently, a detailed exploration of the existing body of research is undertaken with the objective of identifying metabolite biomarkers capable of enhancing current strategies for endometrial cancer diagnosis, prognosis, and recurrence monitoring. Metabolomics holds vast potential to revolutionize the management of endometrial cancer by providing accuracy and valuable insights into crucial aspects.