Effects of cinnamon oil and its main constituents, cinnamic acid and cinnamaldehyde, on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration in PC-12 cells

被引：2

作者：

Bahramsoltani, Roodabeh ^{[1
,2
]}

Shahpiri, Zahra ^{[1
,2
]}

Farzaei, Mohammad Hosein ^{[3
]}

Hosseinzadeh, Leila ^{[3
]}

Rezazadeh, Davood ^{[4
]}

Pourfarzam, Morteza ^{[5
]}

Rahimi, Roja ^{[1
,2
]}

机构：

[1] Univ Tehran Med Sci, Sch Persian Med, Dept Tradit Pharm, Tehran, Iran

[2] Universal Sci Educ & Res Network USERN, PhytoPharmacol Interest Grp PPIG, Tehran, Iran

[3] Kermanshah Univ Med Sci, Hlth Inst, Pharmaceut Sci Res Ctr, Kermanshah, Iran

[4] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran

[5] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan, Iran

来源：

BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS | 2023年 / 22卷 / 06期

关键词：

Persian medicine; Parkinson; Neurodegeneration; Cinnamon; Cinamic acid; Cinamaldehyde; PARKINSONS-DISEASE; TRANS-CINNAMALDEHYDE; DOPAMINERGIC-NEURONS; INHIBITION; ALZHEIMERS; MODEL; NEUROINFLAMMATION; PATHOPHYSIOLOGY; INTERLEUKIN-6; APOPTOSIS;

D O I：

10.37360/blacpma.23.22.6.56

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Cinnamon (Cinnamomum verum J. Presl) is a well-known medicinal plant considered as an effective treatment for neurological disorders based on Persian medicine. The aim of the present study was assessing the effect of cinnamon oil, cinnamic acid, and cinnamaldehyde, on the in vitro model of Parkinson's disease (PD). Cinnamon oil, prepared in sesame oil, was phytochemically analyzed using high performance liquid chromatography (HPLC). Pheochromocytoma-12 (PC-12) cells were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as an in vitro model of neurodegeneration in PD. Cell viability, activity of caspase enzymes, and formation of reactive oxygen species (ROS) were evaluated. MPTP significantly decreased cell viability and increased Casp activity, as well as ROS formation. Cinnamon oil and cinnamic acid at 200 & mu;g/mL could significantly reverse MPTP-induced abnormalities in PC-12 cells including Casp activity and ROS formation. Our study supports the beneficial effect of cinnamon oil in neurodegeneration. Further investigations are needed to clarify the mechanisms and main active components.

引用

页码：837 / 847

页数：11

共 45 条

[1] Investigation the Cytotoxicity of Folate-Conjugated Bismuth Oxide Nanoparticles on KB and A549 Cell Lines [J].