Biomarkers in acute kidney injury - the search for the "renal troponin"

被引：0

作者：

Schanz, Moritz ^{[1
]}

Kimmel, Martin ^{[1
]}

机构：

[1] Robert Bosch Krankenhaus, Abt Allgemeine Innere Med & Nephrol, Auerbachstr 110, D-70376 Stuttgart, Germany

来源：

DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT | 2023年 / 148卷 / 10期

关键词：

acute kidney injury; acute renal failure; biomarkers; early markers; injury markers;

D O I：

10.1055/a-1916-7598

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prognosis of acute kidney injury (AKI) is poor, partly due to significant limitations of the current functional marker-based definition, which results in too small therapeutic window to treat AKI. Therefore, AKI biomarkers are needed to detect AKI earlier. Classical filtration markers are serum creatinine and cystatin C, which, however, show clear limitations for AKI prediction. Early AKI markers are divided into damage markers and "stress" markers. The latter indicate a pre-injury phase with increased AKI risk. The one "renal troponin" will probably never be found because of heterogeneous renal structure and heterogeneous causes of AKI. However, AI-based models with inclusion of biomarkers could significantly improve AKI prediction and prognosis.

引用

页码：610 / 619

页数：10

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