Determination of neotame in various foods by high-performance liquid chromatography coupled with ultraviolet and mass spectrometric detection

被引：13

作者：

Zhu, Kenan ^{[1
]}

Chen, Yihui ^{[1
,3
]}

Yu, Lanlan ^{[3
]}

Hou, Chunyan ^{[1
,4
]}

Qiao, Xiaoqiang ^{[5
]}

Wang, Tingting ^{[1
,2
]}

机构：

[1] Ningbo Univ Technol, Sch Mat & Chem Engn, Ningbo 315211, Peoples R China

[2] Tianjin Univ, Zhejiang Inst, Ningbo 315201, Peoples R China

[3] Ningbo Customs Technol Ctr, Ningbo 315040, Peoples R China

[4] Georgetown Univ, Lombardi Comprehens Canc Ctr, Dept Oncol, Med Ctr, Washington, DC 20057 USA

[5] Hebei Univ, Coll Pharmaceut Sci, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding 071002, Peoples R China

来源：

FOOD CHEMISTRY | 2023年 / 416卷

关键词：

Food; HPLC-UV; HPLC-MS; MS; Neotame; Solid-phase extraction; LOW-CALORIE SWEETENERS; BEVERAGES; ASPARTAME;

D O I：

10.1016/j.foodchem.2023.135863

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new analytical technique involving protein precipitation, heating, lipid degreasing, and SPE procedures combined with HPLC-UV and HPLC-MS/MS has been developed for the determination of neotame in a variety of food samples. This method is applicable for high-protein, high-lipid, or gum-based solid samples. The limit of detection of the HPLC-UV method was 0.5 mu g/mL, while that of the HPLC-MS/MS method was 3.3 ng/mL. The spiked recoveries of neotame in 73 kinds of foods were in the range of 81.1-107.2 % with UV detection. The spiked recoveries obtained by HPLC-MS/MS in 14 kinds of foods ranged from 81.6 % to 105.8 %. This technique was successfully used to determine the contents of neotame in two positive samples, indicating its applicability in food analysis.

引用

页数：8

共 50 条

[21] High-resolution time-of-flight mass spectrometry combined with high-performance liquid chromatography for detection and determination of quinolones and sulfonamides in foods [J].

V. G. Amelin ;

A. I. Korotkov ;

N. M. Volkova .

Journal of Analytical Chemistry, 2015, 70 :1629-1634

[22] Determination of gentamicin in different matrices by a new sensitive high-performance liquid chromatography-mass spectrometric method [J].

Lecaroz, Concepcion ;

Campanero, Miguel A. ;

Gamazo, Carlos ;

Blanco-Prieto, Maria J. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 58 (03) :557-563

[23] High-resolution time-of-flight mass spectrometry combined with high-performance liquid chromatography for detection and determination of quinolones and sulfonamides in foods [J].

Amelin, V. G. ;

Korotkov, A. I. ;

Volkova, N. M. .

JOURNAL OF ANALYTICAL CHEMISTRY, 2015, 70 (14) :1629-1634

[24] Determination of Quinolonones in Food of Animal Origin by Liquid Chromatography Coupled with Fluorescence and Mass Spectrometric Detection [J].

Stoilova, N. ;

Surleva, A. ;

Stoev, G. .

ACTA CHROMATOGRAPHICA, 2014, 26 (04) :599-614

[25] Detection of 10 sweeteners in various foods by liquid chromatography/tandem mass spectrometry [J].

Chang, Chui-Shiang ;

Yeh, Tai Sheng .

JOURNAL OF FOOD AND DRUG ANALYSIS, 2014, 22 (03) :318-328

[26] High-performance liquid chromatography coupled to mass spectrometry for studying new pharmaceutical entities [J].

Chernetsova, E. S. ;

Koryakova, A. G. .

JOURNAL OF ANALYTICAL CHEMISTRY, 2010, 65 (14) :1436-1445

[27] Determination of Retinyl Palmitate and Tocopheryl Acetate in Lipid Microcapsules by High-Performance Liquid Chromatography with Ultraviolet Detection [J].

Bespalova, E. A. ;

Dorozhko, E. V. ;

Guryev, A. M. ;

Alekseeva, M. M. ;

Krivoshchekov, S. V. .

INORGANIC MATERIALS-APPLIED RESEARCH, 2024, 15 (06) :1583-1590

[28] Determination of olanzapine in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection [J].

D'Arrigo, Concetta ;

Migliardi, Gaetana ;

Santoro, Vincenza ;

Spina, Edoardo .

THERAPEUTIC DRUG MONITORING, 2006, 28 (03) :388-393

[29] Rapid and simple method for determination of thiram in fruits and vegetables with high-performance liquid chromatography with ultraviolet detection [J].

Ekroth, SB ;

Ohlin, B ;

Österdahl, BG .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1998, 46 (12) :5302-5304

[30] Determination of Spironolactone and Canrenone in Human Plasma by High-performance Liquid Chromatography with Mass Spectrometry Detection [J].

Vlase, Laurian ;

Imre, Silvia ;

Muntean, Dana ;

Achim, Marcela ;

Muntean, Daniela-Lucia .

CROATICA CHEMICA ACTA, 2011, 84 (03) :361-366

← 1 2 3 4 5 →