Neutrophil Extracellular Traps in Airway Diseases: Pathological Roles and Therapeutic Implications

被引：22

作者：

Jo, Ara ^{[1
]}

Kim, Dae Woo ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Boramae Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Seoul 07061, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

neutrophil extracellular traps; therapeutic targets; airway diseases; asthma; chronic rhinosinusitis; cystic fibrosis; chronic obstructive pulmonary disease; bronchiectasis; coronavirus disease 2019; OBSTRUCTIVE PULMONARY-DISEASE; CXCR2 ANTAGONIST AZD5069; NECROSIS-FACTOR-ALPHA; LUNG-FUNCTION DECLINE; CYSTIC-FIBROSIS; SERINE PROTEASES; INDUCED SPUTUM; SEVERE ASTHMA; CHRONIC RHINOSINUSITIS; NET FORMATION;

D O I：

10.3390/ijms24055034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neutrophils are important effector cells of the innate immune response that fight pathogens by phagocytosis and degranulation. Neutrophil extracellular traps (NETs) are released into the extracellular space to defend against invading pathogens. Although NETs play a defensive role against pathogens, excessive NETs can contribute to the pathogenesis of airway diseases. NETs are known to be directly cytotoxic to the lung epithelium and endothelium, highly involved in acute lung injury, and implicated in disease severity and exacerbation. This review describes the role of NET formation in airway diseases, including chronic rhinosinusitis, and suggests that targeting NETs could be a therapeutic strategy for airway diseases.

引用

页数：20

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