Rift Valley Fever Virus-Infection, Pathogenesis and Host Immune Responses

被引：14
作者：
Nair, Niranjana [1 ]
Osterhaus, Albert D. M. E. [1 ]
Rimmelzwaan, Guus F. [1 ]
Prajeeth, Chittappen Kandiyil [1 ]
机构：
[1] Univ Vet Med Hannover, Res Ctr Emerging Infect & Zoonoses, D-30559 Hannover, Germany
来源：
PATHOGENS | 2023年 / 12卷 / 09期
关键词：
Rift Valley Fever Virus (RVFV); NSs gene; immunity; vaccine; CELL-CYCLE ARREST; DC-SIGN; GENETIC-CHARACTERIZATION; SEROLOGICAL EVIDENCE; ENCEPHALITIS-VIRUS; VACCINE CANDIDATE; CYTOKINE RESPONSE; RHESUS MACAQUES; S-PHASE; MP-12;
D O I：
10.3390/pathogens12091174
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Rift Valley Fever Virus is a mosquito-borne phlebovirus causing febrile or haemorrhagic illness in ruminants and humans. The virus can prevent the induction of the antiviral interferon response through its NSs proteins. Mutations in the NSs gene may allow the induction of innate proinflammatory immune responses and lead to attenuation of the virus. Upon infection, virus-specific antibodies and T cells are induced that may afford protection against subsequent infections. Thus, all arms of the adaptive immune system contribute to prevention of disease progression. These findings will aid the design of vaccines using the currently available platforms. Vaccine candidates have shown promise in safety and efficacy trials in susceptible animal species and these may contribute to the control of RVFV infections and prevention of disease progression in humans and ruminants.
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页数：20
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共 163 条
  • [1] Structural Elucidation of Rift Valley Fever Virus L Protein towards the Discovery of Its Potential Inhibitors
    Alamri, Mubarak A.
    Mirza, Muhammad Usman
    Adeel, Muhammad Muzammal
    Ashfaq, Usman Ali
    Tahir ul Qamar, Muhammad
    Shahid, Farah
    Ahmad, Sajjad
    Alatawi, Eid A.
    Albalawi, Ghadah M.
    Allemailem, Khaled S.
    Almatroudi, Ahmad
    [J]. PHARMACEUTICALS, 2022, 15 (06)
  • [2] Exosomes originating from infection with the cytoplasmic single-stranded RNA virus Rift Valley fever virus (RVFV) protect recipient cells by inducing RIG-I mediated IFN-B response that leads to activation of autophagy
    Alem, Farhang
    Olanrewaju, Adeyemi A.
    Omole, Samson
    Hobbs, Heather E.
    Ahsan, Noor
    Matulis, Graham
    Brantner, Christine A.
    Zhou, Weidong
    Petricoin, Emanuel F.
    Liotta, Lance A.
    Caputi, Massimo
    Bavari, Sina
    Wu, Yuntao
    Kashanchi, Fatah
    Hakami, Ramin M.
    [J]. CELL AND BIOSCIENCE, 2021, 11 (01)
  • [3] A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus
    Allen, Elizabeth R.
    Krumm, Stefanie A.
    Raghwani, Jayna
    Halldorsson, Steinar
    Elliott, Angela
    Graham, Victoria A.
    Koudriakova, Elina
    Harlos, Karl
    Wright, Daniel
    Warimwe, George M.
    Brennan, Benjamin
    Huiskonen, Juha T.
    Dowall, Stuart D.
    Elliott, Richard M.
    Pybus, Oliver G.
    Burton, Dennis R.
    Hewson, Roger
    Doores, Katie J.
    Bowden, Thomas A.
    [J]. CELL REPORTS, 2018, 25 (13): : 3750 - +
  • [4] Rift Valley fever encephalitis
    Alrajhi, AA
    Al-Semari, A
    Al-Watban, J
    [J]. EMERGING INFECTIOUS DISEASES, 2004, 10 (03) : 554 - 555
  • [5] Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine
    Amara, RR
    Villinger, F
    Altman, JD
    Lydy, SL
    O'Neil, SP
    Staprans, SI
    Montefiori, DC
    Xu, Y
    Herndon, JG
    Wyatt, LS
    Candido, MA
    Kozyr, NL
    Earl, PL
    Smith, JM
    Ma, HL
    Grimm, BD
    Hulsey, ML
    McClure, HM
    McNicholl, JM
    Moss, B
    Robinson, HL
    [J]. VACCINE, 2002, 20 (15) : 1949 - 1955
  • [6] Vaccination with Rift Valley fever virus live attenuated vaccine strain Smithburn caused meningoencephalitis in alpacas
    Anthony, Tasneem
    van Schalkwyk, Antoinette
    Romito, Marco
    Odendaal, Lieza
    Clift, Sarah J.
    Davis, Anne S.
    [J]. JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 2021, 33 (04) : 777 - 781
  • [7] Serological Evidence of Antibodies to Rift Valley Fever Virus in Wild and Domestic Animals in Bauchi State, Nigeria
    Atuman, Y. J.
    Kudi, C. A.
    Abdu, P. A.
    Okubanjo, O. O.
    Wungak, Y.
    Ularamu, H. G.
    Abubakar, A.
    [J]. VETERINARY MEDICINE INTERNATIONAL, 2022, 2022
  • [8] p53 Activation following Rift Valley Fever Virus Infection Contributes to Cell Death and Viral Production
    Austin, Dana
    Baer, Alan
    Lundberg, Lindsay
    Shafagati, Nazly
    Schoonmaker, Annalise
    Narayanan, Aarthi
    Popova, Taissia
    Panthier, Jean Jacques
    Kashanchi, Fatah
    Bailey, Charles
    Kehn-Hall, Kylene
    [J]. PLOS ONE, 2012, 7 (05):
  • [9] Induction of DNA Damage Signaling upon Rift Valley Fever Virus Infection Results in Cell Cycle Arrest and Increased Viral Replication
    Baer, Alan
    Austin, Dana
    Narayanan, Aarthi
    Popova, Taissia
    Kainulainen, Markus
    Bailey, Charles
    Kashanchi, Fatah
    Weber, Friedemann
    Kehn-Hall, Kylene
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (10) : 7399 - 7410
  • [10] The NSs Protein Encoded by the Virulent Strain of Rift Valley Fever Virus Targets the Expression of Abl2 and the Actin Cytoskeleton of the Host, Affecting Cell Mobility, Cell Shape, and Cell-Cell Adhesion
    Bamia, Aline
    Marcato, Vasco
    Boissiere, Magali
    Mansuroglu, Zeyni
    Tamietti, Carole
    Romani, Mattea
    Simon, Dominique
    Tian, Guanfang
    Niedergang, Florence
    Panthier, Jean-Jacques
    Flamand, Marie
    Soues, Sylvie
    Bonnefoy, Eliette
    [J]. JOURNAL OF VIROLOGY, 2021, 95 (01)
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