Near-Infrared Visualization Fluoroboron Dipyrrole (BODIPY) Fluorescent Probe with Large Stokes Shift for Detecting Na2S2O4 in vivo

被引：0

作者：

Zhao Xiaolong ^{[1
]}

Guo Liangwu ^{[1
]}

Li Yuqing ^{[1
]}

Ran Qiyuan ^{[1
]}

Wu Huihui ^{[1
]}

Zhang Zhen ^{[1
]}

Su Yingpeng ^{[1
]}

Zhou Pengxin ^{[1
]}

Yan Na ^{[2
]}

机构：

[1] Northwest Normal Univ, Coll Chem & Chem Engn, Minist Educ, Lab Ecoenvironm Related Polymer Mat, Lanzhou 730070, Peoples R China

[2] Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 43卷 / 07期

基金：

中国国家自然科学基金;

关键词：

fluoroboron dipyrrole ( BODIPY); large Stokes shift; visualization; near-infrared; Na2S2O4; TUMOR HYPOXIA; DYES;

D O I：

10.6023/cjoc202210011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Based on the main skeleton of fluoroboron dipyrrole (BODIPY), two near-infrared fluorescent probes Azo-BDP1 and Azo-BDP2 were rationally designed and synthesized with large Stokes shift of 217 and 224 nm, respectively. As two visualized probes for Na2S2O4, Azo-BDP1 and Azo-BDP2 exhibited high sensitivity and selectivity. The reaction-based recognition mechanism was confirmed by mass spectral analysis, in addition, fluorescence imaging studies in zebrafish embryos and zebrafish proved that the probe Azo-BDP1 is suitable for the detection of Na2S2O4 in vivo.

引用

页码：2484 / 2491

页数：8

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