Modulation of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment by Natural Products

被引：5

作者：

Calderon, Jhon Jairo ^{[1
]}

Prieto, Karol ^{[1
]}

Lasso, Paola ^{[1
]}

Fiorentino, Susana ^{[1
]}

Barreto, Alfonso ^{[1
,2
]}

机构：

[1] Pontificia Univ Javeriana, Fac Ciencias, Grp Inmunobiol & Biol Celular, Bogota, Colombia

[2] Pontificia Univ Javeriana, Dept Microbiol, Carrera 7 43-82,Edificio 50 Lab 101, Bogota, Colombia

来源：

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2023年 / 71卷 / 01期

关键词：

Myeloid-derived suppressor cells; MDSCs; Tumor microenvironment; Cancer; Natural products; Phytotherapy; TRANS-RETINOIC ACID; T-CELLS; NETWORK PHARMACOLOGY; STANDARDIZED EXTRACT; PD-L1; EXPRESSION; L-ARGININE; ANTITUMOR; CANCER; INHIBITION; MECHANISM;

D O I：

10.1007/s00005-023-00681-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During carcinogenesis, the microenvironment plays a fundamental role in tumor progression and resistance. This tumor microenvironment (TME) is characterized by being highly immunosuppressive in most cases, which makes it an important target for the development of new therapies. One of the most important groups of cells that orchestrate immunosuppression in TME is myeloid-derived suppressor cells (MDSCs), which have multiple mechanisms to suppress the immune response mediated by T lymphocytes and thus protect the tumor. In this review, we will discuss the importance of modulating MDSCs as a therapeutic target and how the use of natural products, due to their multiple mechanisms of action, can be a key alternative for modulating these cells and thus improve response to therapy in cancer patients.

引用

页数：16

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