Polymerase chain reaction in the diagnosis of invasive aspergillosis: approaches for appropriate use

被引：0

作者：

Keri, Vishakh C. ^{[1
]}

Chandrasekar, Pranatharthi H. ^{[1
]}

机构：

[1] Wayne State Univ, Div Infect Dis, Detroit, MI 48202 USA

来源：

LEUKEMIA & LYMPHOMA | 2023年 / 64卷 / 07期

关键词：

BRONCHOALVEOLAR LAVAGE FLUID; PULMONARY ASPERGILLOSIS; PCR; GALACTOMANNAN; DNA;

D O I：

10.1080/10428194.2023.2209683

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Detection of aspergillus by PCR is a helpful tool for early diagnosis. The test has excellent sensitivity and specificity with a high negative predictive value. Well-accepted, standardized method for DNA extraction for PCR testing is to be adopted for all commercial assays and conclusive validation data are awaited in varied clinical settings. This perspective offers guidance for utilizing PCR testing while awaiting such data. Quantification by PCR, species-specific identification assays and detection of resistance genetic markers are of future promise. Herein, we summarize the available data on aspergillus PCR and describe its potential utility through a clinical case scenario-based approach.

引用

页码：1330 / 1334

页数：5

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