Performance of capillary electrophoresis instruments-State of the art and outlook

被引：20
|
作者：
Hartung, Sophie [1 ]
Minkner, Robert [1 ]
Olabi, Mais [1 ]
Waetzig, Hermann [1 ]
机构：
[1] Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, Beethovenstr 55, D-38106 Braunschweig, Germany
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2023年 / 163卷
关键词：
Capillary electrophoresis; Instrument; Performance; Precision; Speed; Flexibility; Reliability; CONTACTLESS CONDUCTIVITY DETECTION; INDUCED FLUORESCENCE DETECTOR; MASS SPECTROMETRY; CE; VALIDATION; PRECISION; QUALIFICATION; SYSTEM; HPLC;
D O I：
10.1016/j.trac.2023.117056
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The current state of the art of CE instruments and their performance have been reviewed, considering precision, speed, resolution, linearity, sensitivity, ease of use, flexibility, dedication, reliability, costs, and sustainability. Various commercial instruments, home-built ones, and microchip instruments have been compared, as well as different detectors such as UV, fluorescence, capacitively coupled contactless conductivity detectors (C4D), and mass detectors in particular. Performance tests for instruments, qualifications suitable for installation, and performance qualifications (IQ/PQ) have also been reviewed. The peak area precision typically corresponds to approximately 1-2% relative standard deviation (RSD), which is not as good as HPLC. However, this difference between HPLC and CE is often irrelevant, if biotechnical products are investigated, or if substantial sample pre-treatment is required. This evaluation is strongly related to the intended use of the instruments. Today one can find excellent instruments for all applications.(c) 2023 Elsevier B.V. All rights reserved.
引用
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页数：14
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