An Update on Peripheral Blood Extracellular Vesicles as Biomarkers for Parkinson's Disease Diagnosis

被引：6

作者：

Wang, Ke ^{[1
]}

Shen, Jianing ^{[2
]}

Xu, Yan ^{[3
]}

机构：

[1] Zhengzhou Univ, Coll Med, Dept Lab Med, Zhengzhou, Peoples R China

[2] Zhengzhou Univ, Coll Med, Dept Clin Med, Zhengzhou, Peoples R China

[3] Zhengzhou Univ, Sch Basic Med Sci, Dept Med Genet & Cell Biol, Zhengzhou, Peoples R China

来源：

NEUROSCIENCE | 2023年 / 511卷

基金：

中国国家自然科学基金;

关键词：

Parkinson?s disease; peripheral blood; extracellular vesicles; biomarker; disease diagnosis; a-synuclein; GENOME-WIDE ASSOCIATION; LONG NONCODING RNAS; ALPHA-SYNUCLEIN; CEREBROSPINAL-FLUID; IDENTIFIES VARIANTS; ALZHEIMERS-DISEASE; TARGET RECOGNITION; DELIVERY VEHICLES; EXOSOMES; BRAIN;

D O I：

10.1016/j.neuroscience.2022.11.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parkinson's disease (PD) is the world's second primary neurodegenerative disease, and the diagnosis and treatment of PD have become mainstream research. Over the past decades, several studies have identified potential biomarkers for diagnosing PD. Among them, extracellular vesicles (EVs) can carry specific biomarkers reflecting the physiological and pathological state of the body. Due to the blood-brain barrier (BBB) limitation, peripheral blood is limited in diagnosing neurodegenerative diseases. With the increasing research on EVs, their ability to pass through BBB indicated that peripheral blood could depict disease status like cerebrospinal fluid (CSF). Peripheral blood is a clinically available sample and has recently been widely used by researchers in var-ious studies. In this review, we summarized previous studies on PD diagnosis biomarkers in peripheral blood EVs and evaluated their diagnostic value. Some EV surface markers were also described, which can extract EVs from specific cell origins. In addition, the combination of several biomarkers demonstrated good diagnostic perfor-mance in PD diagnosis compared with a single biomarker, suggesting the focus of future research.(c) 2022 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：131 / 146

页数：16

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