Gut microbiota: a potential target for improved cancer therapy

被引：13

作者：

Zhao, Mingkuan ^{[1
,2
]}

Jiang, Gen ^{[1
,2
]}

Zhou, Hu ^{[1
,2
]}

Li, Jiaqi ^{[1
,2
]}

Xiang, Wei ^{[1
,2
]}

Li, Shenjie ^{[1
,2
]}

Wang, Haorun ^{[1
,2
]}

Zhou, Jie ^{[1
,2
,3
,4
]}

机构：

[1] Southwest Med Univ, Affiliated Hosp, Dept Neurosurg, Luzhou, Peoples R China

[2] Neurosurg Clin Med Res Ctr Sichuan Prov, Lu Zhou, Peoples R China

[3] Neurol Dis & Brain Funct Lab, Lu Zhou, Peoples R China

[4] Southwest Med Univ, Affiliated Hosp, Acad Expert Workstat Sichuan Prov, Luzhou, Peoples R China

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2023年 / 149卷 / 01期

关键词：

Gut microbiota; Immunotherapy; Chemotherapy; Radiotherapy; INTESTINAL MICROBIOTA; COLORECTAL-CANCER; EFFICACY; RESISTANCE; PROBIOTICS; IMMUNOTHERAPY; BLOCKADE; CTLA-4;

D O I：

10.1007/s00432-022-04546-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Drug resistance and toxicity are major challenges observed during cancer treatment. In recent years, gut microbiota has been found to be strongly associated with the efficacy, toxicity, and side effects of chemotherapy, radiotherapy, and immunotherapy. Both preclinical studies and clinical trials have demonstrated the potential of microbiota modulation for cancer treatment. The human gut microbiota has exciting prospects for developing biomarkers to predict the outcome of cancer treatment. Moreover, multiple approaches can alter the gut microbiota composition, including faecal microbiota transplantation (FMT), probiotics, antibiotics (ATB), and diet. We describe the mechanisms by which the gut microbiota influences the efficacy and toxicity of cancer therapy, disease-related biomarkers, and methods to target the gut microbiota to improve outcomes. The purpose of this review is to provide new ideas for optimising cancer therapy by providing up-to-date information on the relationship between gut microbiota and cancer therapy, and hopes to find new targets for cancer treatment from human microbiota.

引用

页码：541 / 552

页数：12

共 73 条

[21] Cancer and the microbiota [J].

Garrett, Wendy S. .

SCIENCE, 2015, 348 (6230) :80-86

[22] The future of faecal transplants [J].

Giles, Edward M. ;

D'Adamo, Gemma L. ;

Forster, Samuel C. .

NATURE REVIEWS MICROBIOLOGY, 2019, 17 (12) :719-719

[23] Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients [J].

Gopalakrishnan, V. ;

Spencer, C. N. ;

Nezi, L. ;

Reuben, A. ;

Andrews, M. C. ;

Karpinets, T. V. ;

Prieto, P. A. ;

Vicente, D. ;

Hoffman, K. ;

Wei, S. C. ;

Cogdill, A. P. ;

Zhao, L. ;

Hudgens, C. W. ;

Hutchinson, D. S. ;

Manzo, T. ;

de Macedo, M. Petaccia ;

Cotechini, T. ;

Kumar, T. ;

Chen, W. S. ;

Reddy, S. M. ;

Sloane, R. Szczepaniak ;

Galloway-Pena, J. ;

Jiang, H. ;

Chen, P. L. ;

Shpall, E. J. ;

Rezvani, K. ;

Alousi, A. M. ;

Chemaly, R. F. ;

Shelburne, S. ;

Vence, L. M. ;

Okhuysen, P. C. ;

Jensen, V. B. ;

Swennes, A. G. ;

McAllister, F. ;

Sanchez, E. Marcelo Riquelme ;

Zhang, Y. ;

Le Chatelier, E. ;

Zitvogel, L. ;

Pons, N. ;

Austin-Breneman, J. L. ;

Haydu, L. E. ;

Burton, E. M. ;

Gardner, J. M. ;

Sirmans, E. ;

Hu, J. ;

Lazar, A. J. ;

Tsujikawa, T. ;

Diab, A. ;

Tawbi, H. ;

Glitza, I. C. .

SCIENCE, 2018, 359 (6371) :97-103

[24] Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity [J].

He, Yao ;

Fu, Liuhui ;

Li, Yiping ;

Wang, Wenyan ;

Gong, Mingli ;

Zhang, Jing ;

Dong, Xin ;

Huang, Jiaoyan ;

Wang, Quanbo ;

Mackay, Charles R. ;

Fu, Yang-Xin ;

Chen, Yun ;

Guo, Xiaohuan .

CELL METABOLISM, 2021, 33 (05) :988-+

[25] Cancer drug resistance: an evolving paradigm [J].

Holohan, Caitriona ;

Van Schaeybroeck, Sandra ;

Longley, Daniel B. ;

Johnston, Patrick G. .

NATURE REVIEWS CANCER, 2013, 13 (10) :714-726

[26] Antibiotic use and the efficacy of immune checkpoint inhibitors in cancer patients: a pooled analysis of 2740 cancer patients [J].

Huang, Xuan-Zhang ;

Gao, Peng ;

Song, Yong-Xi ;

Xu, Yan ;

Sun, Jing-Xu ;

Chen, Xiao-Wan ;

Zhao, Jun-Hua ;

Wang, Zhen-Ning .

ONCOIMMUNOLOGY, 2019, 8 (12)

[27] A randomized, double-blind, placebo-controlled trial of probiotics to reduce the severity of oral mucositis induced by chemoradiotherapy for patients with nasopharyngeal carcinoma [J].

Jiang, Chunling ;

Wang, Huan ;

Xia, Chaofei ;

Dong, Qing ;

Chen, En ;

Qiu, Yang ;

Su, Yong ;

Xie, Honghui ;

Zeng, Lei ;

Kuang, Jie ;

Ao, Fan ;

Gong, Xiaochang ;

Li, Jingao ;

Chen, Tingtao .

CANCER, 2019, 125 (07) :1081-1090

[28] A faecal microbiota signature with high specificity for pancreatic cancer [J].

Kartal, Ece ;

Schmidt, Thomas S. B. ;

Molina-Montes, Esther ;

Rodriguez-Perales, Sandra ;

Wirbel, Jakob ;

Maistrenko, Oleksandr M. ;

Akanni, Wasiu A. ;

Alhamwe, Bilal Alashkar ;

Alves, Renato J. ;

Carrato, Alfredo ;

Erasmus, Hans-Peter ;

Estudillo, Lidia ;

Finkelmeier, Fabian ;

Fullam, Anthony ;

Glazek, Anna M. ;

Gomez-Rubio, Paulina ;

Hercog, Rajna ;

Jung, Ferris ;

Kandels, Stefanie ;

Kersting, Stephan ;

Langheinrich, Melanie ;

Marquez, Mirari ;

Molero, Xavier ;

Orakov, Askarbek ;

Van Rossum, Thea ;

Torres-Ruiz, Raul ;

Telzerow, Anja ;

Zych, Konrad ;

Benes, Vladimir ;

Zeller, Georg ;

Trebicka, Jonel ;

Real, Francisco X. ;

Malats, Nuria ;

Bork, Peer .

GUT, 2022, 71 (07) :1359-1372

[29] A review of cancer immunotherapy toxicity [J].

Kennedy, Lucy Boyce ;

Salama, April K. S. .

CA-A CANCER JOURNAL FOR CLINICIANS, 2020, 70 (02) :86-104

[30] High-throughput 16S rRNA gene sequencing reveals alterations of mouse intestinal microbiota after radiotherapy [J].

Kim, Young Suk ;

Kim, Jinu ;

Park, Soo-Je .

ANAEROBE, 2015, 33 :1-7

← 1 2 3 4 5 6 7 8 →