Role of Intestinal Microbiota in the Pathogenesis of Colorectal Cancer: A Narrative Review

被引：0

作者：

Menon, Sharanya ^{[1
]}

Kadhit, Kanishk ^{[1
]}

Shukla, Samarth ^{[2
]}

Acharya, Sourya ^{[1
]}

机构：

[1] DMIMS DU, Jawaharlal Nehru Med Coll, Dept Med, Wardha 442004, Maharashtra, India

[2] DMIMS DU, Jawaharlal Nehru Med Coll, Dept Pathol, Wardha, Maharashtra, India

来源：

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH | 2024年 / -18卷 / 01期

关键词：

Diet; Dysbiosis; Gastrointestinal malignancy; Inflammation; Screening; GUT MICROBIOTA;

D O I：

10.7860/JCDR/2024/60755.18860

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The human gut microbiota forms a biome and acts as a neglected organ, playing vital roles in organ integrity, metabolism, immunity, and homeostasis. Variations in the microbiome can lead to disease initiation. Research using bacterial sequencing of faeces and digestive tissues has focused on understanding the role of gut microbiota in cancer development, particularly Colorectal Cancer (CRC), Dysbiosis and modifications in the intestinal microbiota have been observed in CRC cases. Hypotheses like the alpha bug hypothesis and the driver-passenger model aim to explain the correlation between gut microbiota and CRC pathogenesis. The present article summarise the functions of gut microbiota, mechanisms involved in colorectal carcinogenesis, and discusses the clinical significance of gut microbiota in CRC screening and therapy.

引用

页码：OE1 / OE5

页数：5

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