Absence of Type I Interferon Autoantibodies or Significant Interferon Signature Alterations in Adults With Post-COVID-19 Syndrome

被引：2

作者：

Achleitner, Martin ^{[1
]}

Mair, Nina K. ^{[2
,3
,4
]}

Daenhardt, Juliane ^{[1
]}

Kardashi, Romina ^{[1
]}

Puhan, Milo A. ^{[5
]}

Abela, Irene A. ^{[2
,6
]}

Toepfner, Nicole ^{[7
]}

de With, Katja ^{[8
]}

Kanczkowski, Waldemar ^{[1
]}

Jarzebska, Natalia ^{[1
]}

Rodionov, Roman N. ^{[1
]}

Wolf, Christine ^{[7
]}

Lee-Kirsch, Min Ae ^{[7
]}

Steenblock, Charlotte ^{[1
,12
]}

Hale, Benjamin G. ^{[2
]}

Bornstein, Stefan R. ^{[1
,9
,10
,11
]}

机构：

[1] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Internal Med 3, Dresden, Germany

[2] Univ Zurich, Inst Med Virol, Zurich, Switzerland

[3] ETH, Life Sci Zurich Grad Sch, CH-8057 Zurich, Switzerland

[4] Univ Zurich, Zurich, Switzerland

[5] Univ Zurich, Epidemiol Biostat & Prevent Inst, Zurich, Switzerland

[6] Univ Hosp Zurich, Dept Infect Dis & Hosp Epidemiol, Zurich, Switzerland

[7] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Pediat, Dresden, Germany

[8] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Div Infect Dis, Dresden, Germany

[9] Kings Coll London, Fac Life Sci & Med, Sch Cardiovasc & Metab Med & Sci, London, England

[10] Univ Hosp Zurich, Dept Endocrinol Diabetol & Clin Nutr, Zurich, Switzerland

[11] Univ Zurich, Zurich, Switzerland

[12] Tech Univ Dresden, Dept Internal Med 3, Fetscherstr 74, D-01307 Dresden, Germany

来源：

OPEN FORUM INFECTIOUS DISEASES | 2024年 / 11卷 / 01期

关键词：

autoantibodies; COVID-19; interferon; post-COVID-19; syndrome;

D O I：

10.1093/ofid/ofad641

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genetic defects in the interferon (IFN) system or neutralizing autoantibodies against type I IFNs contribute to severe COVID-19. Such autoantibodies were proposed to affect post-COVID-19 syndrome (PCS), possibly causing persistent fatigue for >12 weeks after confirmed SARS-CoV-2 infection. In the current study, we investigated 128 patients with PCS, 21 survivors of severe COVID-19, and 38 individuals who were asymptomatic. We checked for autoantibodies against IFN-alpha, IFN-beta, and IFN-omega. Few patients with PCS had autoantibodies against IFNs but with no neutralizing activity, indicating a limited role of type I IFNs in PCS pathogenesis. In a subset consisting of 28 patients with PCS, we evaluated IFN-stimulated gene activity and showed that it did not correlate with fatigue. In conclusion, impairment of the type I IFN system is unlikely responsible for adult PCS.

引用

页数：5

共 29 条

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