Sex differences in brain atrophy in dementia with Lewy bodies

被引：9

作者：

Oltra, Javier ^{[1
,2
,3
]}

Habich, Annegret ^{[3
,4
]}

Schwarz, Christopher G. ^{[5
]}

Nedelska, Zuzana ^{[6
,7
]}

Przybelski, Scott A. ^{[8
]}

Inguanzo, Anna ^{[3
]}

Diaz-Galvan, Patricia ^{[5
]}

Lowe, Val J. ^{[5
]}

Oppedal, Ketil ^{[9
,10
,11
]}

Gonzalez, Maria C. ^{[9
,10
,11
,12
]}

Philippi, Nathalie ^{[13
,14
,15
]}

Blanc, Frederic ^{[13
,14
,15
]}

Barkhof, Frederik ^{[16
,17
,18
]}

Lemstra, Afina W. ^{[19
,20
]}

Hort, Jakub ^{[6
,7
]}

Padovani, Alessandro ^{[21
]}

Rektorova, Irena ^{[22
]}

Bonanni, Laura ^{[23
]}

Massa, Federico ^{[24
]}

Kramberger, Milica G. ^{[25
]}

Taylor, John-Paul ^{[26
]}

Snaedal, Jon G. ^{[27
]}

Walker, Zuzana ^{[28
,29
]}

Antonini, Angelo ^{[30
]}

Dierks, Thomas ^{[4
]}

Segura, Barbara ^{[1
,2
,31
]}

Junque, Carme ^{[1
,2
,31
]}

Westman, Eric ^{[3
]}

Boeve, Bradley F. ^{[32
]}

Aarsland, Dag ^{[9
,33
]}

Kantarci, Kejal ^{[5
]}

Ferreira, Daniel ^{[3
,5
,34
]}

机构：

[1] Univ Barcelona, Inst Neurosci, Dept Med, Med Psychol Unit, Barcelona, Catalonia, Spain

[2] Inst Biomed Res August Pi & Sunyer IDIBAPS, Barcelona, Catalonia, Spain

[3] Karolinska Inst, Div Clin Geriatr, Ctr Alzheimer Res, Dept Neurobiol Care Sci & Soc, Blickagangen 16,Neo 7th Floor, S-14183 Stockholm, Sweden

[4] Univ Bern, Univ Hosp Psychiat & Psychotherapy, Bern, Switzerland

[5] Mayo Clin, Dept Radiol, Rochester, MN USA

[6] Charles Univ Prague, Dept Neurol, Fac Med 2, Memory Clin, Prague, Czech Republic

[7] Motol Univ Hosp, Prague, Czech Republic

[8] Mayo Clin, Dept Quantitat Hlth Sci, Rochester, MN USA

[9] Stavanger Univ Hosp, Ctr Age Related Med, Stavanger, Norway

[10] Stavanger Univ Hosp, Dept Radiol, SMIL, Stavanger, Norway

[11] Stavanger Univ Hosp, Norwegian Ctr Movement Disorders, Stavanger, Norway

[12] Univ Stavanger, Fac Hlth Sci, Dept Qual & Hlth Technol, Stavanger, Norway

[13] Hop Univ Strasbourg, Res & Resources Memory Ctr CM2R, Geriatr Unit, F-67000 Strasbourg, France

[14] Hop Univ Strasbourg, Res & Resources Memory Ctr CM2R, Neurol Unit, F-67000 Strasbourg, France

[15] CNRS, UMR 7357, ICUBE Lab, Strasbourg, France

[16] Vrije Univ, Dept Radiol & Nucl Med AMC, Amsterdam UMC, Amsterdam, Netherlands

[17] UCL, Queen Sq Inst Neurol, London, England

[18] UCL, Ctr Med Image Comp CMIC, London, England

[19] Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Neurol, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands

[20] Vrije Univ Amsterdam, Amsterdam UMC Locat VUmc, Amsterdam Neurosci, Neurodegenerat, Amsterdam, Netherlands

[21] Univ Brescia, Dept Clin & Expt Sci DSCS, Neurol Unit, Brescia, Italy

[22] Masaryk Univ, Cent European Inst Technol CEITET, Brain & Mind Res, Brno, Czech Republic

[23] Univ G Annunzio Chieti Pescara Chieti, Dept Med & Aging Sci, Chieti, Italy

[24] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy

[25] Univ Med Ctr Ljubljana, Dept Neurol, Ljubljana, Slovenia

[26] Newcastle Univ, Translat & Clin Res Inst, Fac Med Sci, Newcastle Upon Tyne, Northumberland, England

[27] Landspitali, Memory Clin, Reykjavik, Iceland

[28] UCL, Div Psychiat, London, England

[29] Essex Partnership Univ NHS Fdn Trust, St Margarets Hosp, Runwell, Wickford, England

[30] Study Ctr Neurodegenerat CESNE, Parkinson & Movement Disorders Unit, Padua, Italy

[31] Network Ctr Biomed Res Neurodegenerat Dis CIBERNE, Barcelona, Catalonia, Spain

[32] Mayo Clin, Dept Neurol, Rochester, MN USA

[33] Kings Coll London, Dept Old Age Psychiat, Inst Psychiat Psychol & Neurosci, London, England

[34] Univ Fernando Pessoa Canarias, Fac Ciencias Salud, Las Palmas Gran Canaria, Spain

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 03期

基金：

美国国家卫生研究院; 瑞典研究理事会;

关键词：

atrophy; dementia with Lewy bodies; magnetic resonance imaging; sex differences; ALZHEIMERS-DISEASE; CORTICAL THICKNESS; CEREBROVASCULAR-DISEASE; CLINICAL PHENOTYPE; GENDER; DIAGNOSIS; REGISTRATION; IMPAIRMENT; BIOMARKERS; MANAGEMENT;

D O I：

10.1002/alz.13571

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTIONSex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI).METHODSWe included 436 patients from the European-DLB consortium and the Mayo Clinic. Sex differences and sex-by-age interactions were assessed through visual atrophy rating scales (n = 327; 73 +/- 8 years, 62% males) and automated estimations of regional gray matter volume and cortical thickness (n = 165; 69 +/- 9 years, 72% males).RESULTSWe found a higher likelihood of frontal atrophy and smaller volumes in six cortical regions in males and thinner olfactory cortices in females. There were significant sex-by-age interactions in volume (six regions) and cortical thickness (seven regions) across the entire cortex.DISCUSSIONWe demonstrate that males have more widespread cortical atrophy at younger ages, but differences tend to disappear with increasing age, with males and females converging around the age of 75.HighlightsMale DLB patients had higher odds for frontal atrophy on radiological visual rating scales.Male DLB patients displayed a widespread pattern of cortical gray matter alterations on automated methods.Sex differences in gray matter measures in DLB tended to disappear with increasing age.

引用

页码：1815 / 1826

页数：12

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