Children's Oncology Group's 2023 blueprint for research: Development therapeutics

被引：3
|
作者：
Fox, Elizabeth [1 ]
Parsons, D. Williams J. [2 ]
Weigel, Brenda [3 ,4 ]
Dev Therapeutics Comm
机构：
[1] St Jude Childrens Res Hosp, Memphis, TN USA
[2] Baylor Coll Med, Texas Childrens Canc & Hematol Ctr, Houston, TX USA
[3] Univ Minnesota, Div Pediat Hematol & Oncol, Med Ctr, Minneapolis, MN USA
[4] Univ Minnesota, Div Pediat Hematol & Oncol, Med Ctr, Mail Code 484,420 Delaware St SE, Minneapolis, MN 55455 USA
来源：
PEDIATRIC BLOOD & CANCER | 2023年 / 70卷
关键词：
phase; 2; precision medicine; trial design; PATHWAY; TRIAL;
D O I：
10.1002/pbc.30563
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The Developmental Therapeutics Committee (DVL) identifies and develops new agents and treatment strategies for children/adolescents with cancer, through clinical and translational research. DVL has focused on evaluating the activity of targeted therapy and has evolved from trials with multiple histology strata to biomarker-selected phase 2 trials. These trials have included single-agent studies to evaluate agents such as cabozantinib in multi-disease cohorts, to trametinib, larotrectinib, and lorvotuzumab in disease-specific cohorts, as well as the pediatric Molecular Analysis for Therapy Choice (MATCH) study including multiple single agents targeted for biomarker-selected pediatric tumors. The ongoing vision and direction of DVL is to support the disease committees of COG to develop novel agents and combinations to advance the care of children with cancer.
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页数：5
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