Metal-free organic catalyst for synthesis of low dispersity poly(ethylene glycol-block-polylactide) copolymers with well-defined structure

被引：0
作者：
Puchkova, Yulia A. [1 ]
Sedush, Nikita G. [1 ,2 ]
Ivanenko, Antonina D. [1 ]
Shuvatova, Valentina G. [1 ]
Posypanova, Galina A. [1 ]
Chvalun, Sergei N. [1 ,2 ]
机构：
[1] Natl Res Ctr Kurchatov Inst, Moscow 123182, Russia
[2] Russian Acad Sci, NS Enikolopov Inst Synthet Polymer Mat, Moscow 117393, Russia
来源：
MENDELEEV COMMUNICATIONS | 2023年 / 33卷 / 03期
基金：
俄罗斯科学基金会;
关键词：
metal-free ring opening polymerization; DBU; block copolymers; poly(lactide); poly(ethylene glycol); nanoparticles; drug delivery systems; DRUG-DELIVERY; LACTIDE;
D O I：
10.1016/j.mencom.2023.04.033
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Ring-opening polymerization of lactide was performed in the presence of 1,8-diazabicyclo[5.4.0]undec-5-ene as an organic catalyst and polyethylene glycol as a hydroxyl-containing macroinitiator. A series of amphiphilic poly(ethylene glycol-block-polylactide) copolymers with a low dispersity (PDI = 1.1), different stereoregularity and length of the polylactide block was obtained. Nanoparticles with a diameter of 20-25 nm were produced from selected polymers and were studied by in vitro cytotoxicity tests.
引用
收藏
页码：404 / 407
页数：4
相关论文
共 20 条
  • [1] ALLEY MC, 1988, CANCER RES, V48, P589
  • [2] Polymers for the future
    Arzhakova, Olga, V
    Arzhakov, Maxim S.
    Badamshina, Elmira R.
    Bryuzgina, Ekaterina B.
    Bryuzgin, Evgeny, V
    Bystrova, Aleksandra, V
    Vaganov, Gleb V.
    Vasilevskaya, Valentina V.
    Vdovichenko, Artem Yu
    Gallyamov, Marat O.
    Gumerov, Rustam A.
    Didenko, Andrey L.
    Zefirov, Vadim V.
    Karpov, Sergei, V
    Komarov, Pavel, V
    Kulichikhin, Valery G.
    Kurochkin, Sergei A.
    Larin, Sergey, V
    Malkin, Alexander Ya
    Milenin, Sergey A.
    Muzafarov, Aziz M.
    Molchanov, Vyacheslav S.
    Navrotskiy, Alexander, V
    Novakov, Ivan A.
    Panarin, Evgenii F.
    Panova, Irina G.
    Potemkin, Igor I.
    Svetlichny, Valentin M.
    Sedush, Nikita G.
    Serenko, Olga A.
    Uspenskii, Sergey A.
    Philippova, Olga E.
    Khokhlov, Alexei R.
    Chvalun, Sergei N.
    Sheiko, Sergei S.
    Shibaev, Andrey, V
    Elmanovich, Igor, V
    Yudin, Vladimir E.
    Yakimansky, Alexander, V
    Yaroslavov, Alexander A.
    [J]. RUSSIAN CHEMICAL REVIEWS, 2022, 91 (12)
  • [3] Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo
    Ashton, Susan
    Song, Young Ho
    Nolan, Jim
    Cadogan, Elaine
    Murray, Jim
    Odedra, Rajesh
    Foster, John
    Hall, Peter A.
    Low, Susan
    Taylor, Paula
    Ellston, Rebecca
    Polanska, Urszula M.
    Wilson, Joanne
    Howes, Colin
    Smith, Aaron
    Goodwin, Richard J. A.
    Swales, John G.
    Strittmatter, Nicole
    Takats, Zoltan
    Nilsson, Anna
    Andren, Per
    Trueman, Dawn
    Walker, Mike
    Reimer, Corinne L.
    Troiano, Greg
    Parsons, Donald
    De Witt, David
    Ashford, Marianne
    Hrkach, Jeff
    Zale, Stephen
    Jewsbury, Philip J.
    Barry, Simon T.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2016, 8 (325)
  • [4] Organic Catalysis for Ring-Opening Polymerization
    Dove, Andrew P.
    [J]. ACS MACRO LETTERS, 2012, 1 (12): : 1409 - 1412
  • [5] Synthesis of lactide from alkyl lactates catalyzed by lanthanide salts
    Egiazaryan, Tatevik A.
    Makarov, Valentin M.
    Moskalev, Mikhail, V
    Razborov, Danila A.
    Fedushkin, Igor L.
    [J]. MENDELEEV COMMUNICATIONS, 2019, 29 (06) : 648 - 650
  • [6] Poly(Ethylene Glycol)-b-Poly(D,L-Lactide) Nanoparticles as Potential Carriers for Anticancer Drug Oxaliplatin
    Kadina, Yulia A.
    Razuvaeva, Ekaterina V.
    Streltsov, Dmitry R.
    Sedush, Nikita G.
    Shtykova, Eleonora V.
    Kulebyakina, Alevtina I.
    Puchkov, Alexander A.
    Volkov, Dmitry S.
    Nazarov, Alexey A.
    Chvalun, Sergei N.
    [J]. MOLECULES, 2021, 26 (03):
  • [7] Size-Dependent EPR Effect of Polymeric Nanoparticles on Tumor Targeting
    Kang, Homan
    Rho, Sunghoon
    Stiles, Wesley R.
    Hu, Shuang
    Baek, Yoonji
    Hwang, Do Won
    Kashiwagi, Satoshi
    Kim, Moon Suk
    Choi, Hak Soo
    [J]. ADVANCED HEALTHCARE MATERIALS, 2020, 9 (01)
  • [8] Key aspects to yield low dispersity of PEO-b-PCL diblock copolymers and their mesoscale self-assembly
    Konishcheva, Evgeniia
    Haussinger, Daniel
    Lorcher, Samuel
    Meier, Wolfgang
    [J]. EUROPEAN POLYMER JOURNAL, 2016, 83 : 300 - 310
  • [9] The 35th Anniversary of the Discovery of EPR Effect: A New Wave of Nanomedicines for Tumor-Targeted Drug Delivery-Personal Remarks and Future Prospects
    Maeda, Hiroshi
    [J]. JOURNAL OF PERSONALIZED MEDICINE, 2021, 11 (03):
  • [10] Role of self-assembly conditions and amphiphilic balance on nanoparticle formation of PEG-PDLLA copolymers in aqueous environments
    Phan, Hien
    Minut, Robert, I
    McCrorie, Phoebe
    Vasey, Catherine
    Larder, Ryan R.
    Krumins, Eduards
    Marlow, Maria
    Rahman, Ruman
    Alexander, Cameron
    Taresco, Vincenzo
    Pearce, Amanda K.
    [J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2019, 57 (17) : 1801 - 1810
12