Safety and immunogenicity of heterologous ChAdOx1-nCoV19 and BNT162b2 vaccination: A meta-analysis of the heterologous COVID-19 vaccination outcomes

被引：2

作者：

Hu, Yuxuan ^{[1
]}

Wang, Yanning ^{[2
]}

Shao, Taihang ^{[3
]}

Tang, Wenxi ^{[3
]}

Hu, Kerong ^{[4
]}

Zhou, Yujie ^{[5
]}

Miao, Liyun ^{[5
]}

Liu, Jing ^{[6
]}

Wang, Bin ^{[2
]}

Yu, Wenying ^{[1
]}

机构：

[1] China Pharmaceut Univ, Inst Pharmaceut Sci, Nanjing 211198, Peoples R China

[2] Nanjing Univ, Affiliated Drum Tower Hosp, Clin Stem Cell Ctr, Med Sch, 321 Zhongshan Rd, Nanjing 210008, Peoples R China

[3] China Pharmaceut Univ, Sch Int Pharmaceut Business, Dept Pharmacoecon, Nanjing 211198, Peoples R China

[4] Huangshi Love & Hlth Hosp, Dept Infect Dis, Huangshi 435000, Peoples R China

[5] Nanjing Drum Tower Hosp, Dept Resp & Crit Care Med, Nanjing 210008, Peoples R China

[6] Nanjing Yuhua Hosp, Nanjing Hosp 1, Yuhua Branch, Clin Lab, Nanjing 210039, Peoples R China

来源：

VACCINE | 2023年 / 41卷 / 18期

关键词：

COVID-19; SARS-CoV-2; Heterologous vaccination; Immunogenicity; Meta-analysis; NCOV-19;

D O I：

10.1016/j.vaccine.2023.03.056

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Introduction: Here, we systematically assessed the safety and immunogenicity of the heterologous ChAd/ BNT vaccination regimens.Materials and methods: We evaluated the immunogenicity by the geometric mean titers ratio (GMTR) of the neutralizing antibody and anti-spike IgG. The safety of heterologous ChAd/BNT vaccination was evaluated using the pooled risk ratios (RRs) calculated by the random-effects model about the adverse events. Our study was registered with PROSPERO, CRD42021265165.Results: Eleven studies were included in the analyses. Compared to the homologous ChAd/ChAd vaccination, the heterologous ChAd/BNT vaccination showed significantly higher immunogenicity in terms of the neutralizing antibody and GMTR of anti-spike IgG, but at the same time displayed higher incidence of total adverse reactions, especially for the local adverse reactions. Moreover, heterologous ChAd/BNT vaccination showed similar immunogenicity to the homologous BNT/BNT vaccination (GMTR of neutralizing antibody and anti-spike IgG) and similar safety.Discussion: Heterologous ChAd/BNT vaccination showed robust immunogenicity and tolerable safety. (c) 2023 Elsevier Ltd. All rights reserved.

引用

页码：3003 / 3010

页数：8

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