Immune checkpoint inhibitors in non-conventional histologies of renal-cell carcinoma

被引：9

作者：

Bersanelli, Melissa ^{[1
,7
]}

Rebuzzi, Sara Elena ^{[2
,3
]}

Roviello, Giandomenico ^{[4
]}

Catalano, Martina ^{[4
]}

Brunelli, Matteo ^{[5
]}

Rizzo, Mimma ^{[6
]}

机构：

[1] Univ Hosp Parma, Med Oncol Unit, Parma, Italy

[2] Osped San Paolo, Med Oncol Unit, Savona, Italy

[3] Univ Genoa, Dept Internal Med & Med Specialties Di M I, Genoa, Italy

[4] Univ Florence, Dept Hlth Sci, Florence, Italy

[5] Univ Verona, Dept Pathol, Azienda Osped Univ Integrata Verona, Verona, Italy

[6] Azienda Osped Univ Consorziale Policlin Bari, Med Oncol Unit, Bari, Italy

[7] Univ Hosp Parma, Med Oncol Unit, Via Gramsci 14, I-43126 Parma, Italy

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2023年 / 19卷 / 01期

关键词：

Non-clear cell renal carcinoma; nccRCC; immune checkpoint inhibitors; anti-PD-1; papillary renal cell carcinoma; chromophobe renal cell carcinoma; MiTF translocation; collecting duct carcinoma; Sarcomatoid RCC; kidney cancer; COLLECTING DUCT CARCINOMA; OPEN-LABEL; MULTICENTER; METAANALYSIS; SUNITINIB; PD-L1;

D O I：

10.1080/21645515.2023.2171672

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

For years, prospective randomized clinical trials excluded patients with non-conventional histologies of renal cell carcinoma (RCC). The paucity of data has led to adopting the same treatment strategies used for clear-cell RCC (ccRCC). In the present narrative review, we explored state of the art about use of immune checkpoint inhibitors (ICIs) in variant histologies of RCC. According to the results collected, ICIs as monotherapy showed promising antitumor activity in advanced non-clear cell (ncc)RCC. The objective response rate (ORR) was similar to that observed with single-agent anti-PD-1 in the ccRCC population, either in the first-line or the second-line setting, and responder patients experienced an early and durable benefit. Combined ICI-based strategies have shown increasing evidence in nccRCC and robust results in the sarcomatoid variants of RCC. A definitive recommendation about treating non-conventional histologies, either in adjuvant or metastatic settings, should be supported by more extensive dedicated trials.

引用

页数：11

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