Transcription Factor MYB as Therapeutic Target: Current Developments

被引：4

作者：

Klempnauer, Karl-Heinz ^{[1
]}

机构：

[1] Univ Munster, Inst Biochem, D-48149 Munster, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 06期

关键词：

MYB; inhibitor; AML; leukemia; adenoid cystic carcinoma; transcription; p300; gene expression; ACUTE MYELOID-LEUKEMIA; CREB-BINDING PROTEIN; C-MYB; V-MYB; KIX DOMAIN; CELL-CYCLE; P300; EXPRESSION; ONCOGENE; GENE;

D O I：

10.3390/ijms25063231

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The MYB protein is a pivotal player in the cellular transcriptional network, influencing major important processes such as cell proliferation, differentiation, and apoptosis. Because of its role in oncogenesis, MYB is now a compelling target for therapeutic interventions in cancer research. This review summarizes its molecular functions and current therapeutic approaches aiming to inhibit its oncogenic activity.

引用

页数：12

共 103 条

[1] A synthetic covalent ligand of the C/EBPβ transactivation domain inhibits acute myeloid leukemia cells [J].

Frank, Daria ;

Moorthy, Ramkumar ;

Widen, John C. ;

Khandanpour, Cyrus ;

Harki, Daniel A. ;

Klempnauer, Karl-Heinz ;

Ghani, Luca Abdel ;

Yusenko, Maria V. ;

Doerner, Wolfgang .

CANCER LETTERS, 2022, 530 :170-180

[2] MYB sustains hypoxic survival of pancreatic cancer cells by facilitating metabolic reprogramming [J].

Anand, Shashi ;

Khan, Mohammad Aslam ;

Zubair, Haseeb ;

Sudan, Sarabjeet Kour ;

Vikramdeo, Kunwar Somesh ;

Deshmukh, Sachin Kumar ;

Azim, Shafquat ;

Srivastava, Sanjeev Kumar ;

Singh, Seema ;

Singh, Ajay Pratap .

EMBO REPORTS, 2023, 24 (03)

[3] ATR is a MYB regulated gene and potential therapeutic target in adenoid cystic carcinoma [J].

Andersson, Mattias K. ;

Mangiapane, Giovanna ;

Nevado, Paloma Tejera ;

Tsakaneli, Alexia ;

Carlsson, Therese ;

Corda, Gabriele ;

Nieddu, Valentina ;

Abrahamian, Carla ;

Chayka, Olesya ;

Rai, Lilam ;

Wick, Michael ;

Kedaigle, Amanda ;

Stenman, Goran ;

Sala, Arturo .

ONCOGENESIS, 2020, 9 (01)

[4] AN OLIGOMER COMPLEMENTARY TO C-MYB-ENCODED MESSENGER-RNA INHIBITS PROLIFERATION OF HUMAN MYELOID-LEUKEMIA CELL-LINES [J].

ANFOSSI, G ;

GEWIRTZ, AM ;

CALABRETTA, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (09) :3379-3383

[5] MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism [J].

Bandopadhayay, Pratiti ;

Ramkissoon, Lori A. ;

Jain, Payal ;

Bergthold, Guillaume ;

Wala, Jeremiah ;

Zeid, Rhamy ;

Schumacher, Steven E. ;

Urbanski, Laura ;

O'Rourke, Ryan ;

Gibson, William J. ;

Pelton, Kristine ;

Ramkissoon, Shakti H. ;

Han, Harry J. ;

Zhu, Yuankun ;

Choudhari, Namrata ;

Silva, Amanda ;

Boucher, Katie ;

Henn, Rosemary E. ;

Kang, Yun Jee ;

Knoff, David ;

Paolella, Brenton R. ;

Gladden-Young, Adrianne ;

Varlet, Pascale ;

Pages, Melanie ;

Horowitz, Peleg M. ;

Federation, Alexander ;

Malkin, Hayley ;

Tracy, Adam A. ;

Seepo, Sara ;

Ducar, Matthew ;

Van Hummelen, Paul ;

Santi, Mariarita ;

Buccoliero, Anna Maria ;

Scagnet, Mirko ;

Bowers, Daniel C. ;

Giannini, Caterina ;

Puget, Stephanie ;

Hawkins, Cynthia ;

Tabori, Uri ;

Klekner, Almos ;

Bognar, Laszlo ;

Burger, Peter C. ;

Eberhart, Charles ;

Rodriguez, Fausto J. ;

Hill, D. Ashley ;

Mueller, Sabine ;

Haas-Kogan, Daphne A. ;

Phillips, Joanna J. ;

Santagata, Sandro ;

Stiles, Charles D. .

NATURE GENETICS, 2016, 48 (03) :273-282

[6] In vivo expression of an aberrant MYB-GATA1 fusion induces leukemia in the presence of GATA1 reduced levels [J].

Belloni, E. ;

Shing, D. ;

Tapinassi, C. ;

Viale, A. ;

Mancuso, P. ;

Malazzi, O. ;

Gerbino, E. ;

Dall'Olio, V. ;

Egurbide, I. ;

Odero, M. D. ;

Bertolini, F. ;

Pelicci, P. Giuseppe .

LEUKEMIA, 2011, 25 (04) :733-736

[7] c-Myb Binding Sites in Haematopoietic Chromatin Landscapes [J].

Bengtsen, Mads ;

Klepper, Kjetil ;

Gundersen, Sveinung ;

Cuervo, Ignacio ;

Drablos, Finn ;

Hovig, Eivind ;

Sandve, Geir Kjetil ;

Gabrielsen, Odd Stokke ;

Eskeland, Ragnhild .

PLOS ONE, 2015, 10 (07)

[8] Identification of small-molecule antagonists that inhibit an activator: coactivator interaction [J].

Best, JL ;

Amezcua, CA ;

Mayr, B ;

Flechner, L ;

Murawsky, CM ;

Emerson, B ;

Zor, T ;

Gardner, KH ;

Montminy, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (51) :17622-17627

[9] VIRAL MYB ONCOGENE ENCODES A SEQUENCE-SPECIFIC DNA-BINDING ACTIVITY [J].

BIEDENKAPP, H ;

BORGMEYER, U ;

SIPPEL, AE ;

KLEMPNAUER, KH .

NATURE, 1988, 335 (6193) :835-837

[10] c-Myb and Bcl-x overexpression predicts poor prognosis in colorectal cancer -: Clinical and experimental findings [J].

Biroccio, A ;

Benassi, B ;

D'Agnano, I ;

D'Angelo, C ;

Buglioni, S ;

Mottolese, M ;

Ricciotti, A ;

Citro, G ;

Cosimelli, M ;

Ramsay, RG ;

Calabretta, B ;

Zupi, G .

AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (04) :1289-1299

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