Revolutionizing colorectal cancer treatment: unleashing the potential of miRNAs in targeting cancer stem cells

被引：3
作者：
Osei, George Yiadom [1 ,2 ]
Adu-Amankwaah, Joseph [3 ]
Koomson, Selina [2 ]
Beletaa, Solomon [2 ]
Ahmad, Muhammad Khairi [1 ]
Asiamah, Emmanuel Akomanin [2 ,4 ,5 ]
Smith-Togobo, Cecilia [2 ]
Razak, Siti Razila Abdul [1 ]
机构：
[1] Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, Kepala Batas 13200, Pulau Pinang, Malaysia
[2] Univ Hlth & Allied Sci, Dept Med Lab Sci, PMB 31, Ho, Ghana
[3] Xuzhou Med Univ, Dept Physiol, Xuzhou, Peoples R China
[4] Univ KwaZulu Natal, Sch Nursing & Publ Hlth, Discipline Publ Hlth Med, ZA-4001 Durban, South Africa
[5] Univ KwaZulu Natal, Coll Hlth Sci, Canc & Infect Dis Epidemiol Res Unit CIDERU, ZA-4001 Durban, South Africa
来源：
FUTURE ONCOLOGY | 2023年 / 19卷 / 35期
关键词：
cancer stem cells; colorectal cancer; miRNA; miRNA-based therapies; miRNA delivery; stemness; targeted therapy; therapy resistance; COLON; CHEMORESISTANCE; RESISTANCE; PROLIFERATION; METASTASIS; LINES; OLIGONUCLEOTIDES; INHIBITION; STERNNESS; CARCINOMA;
D O I：
10.2217/fon-2023-0426
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colorectal cancer (CRC) is a significant contributor to cancer mortality worldwide, and the presence of cancer stem cells (CSC) represents a major challenge for achieving effective treatment. miRNAs have emerged as critical regulators of gene expression, and recent studies have highlighted their role in regulating stemness and therapeutic resistance in CRC stem cells. This review highlights the mechanisms of CSC development, therapy resistance and the potential of miRNAs as therapeutic targets for CRC. It emphasizes the promise of miRNAs as a novel approach to CRC treatment and calls for further research to explore effective miRNA-based therapies and strategies for delivering miRNAs to CSCs in vivo.
引用
收藏
页码：2369 / 2382
页数：14
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