Decoding the IL-33/ST2 Axis: Its Impact on the Immune Landscape of Breast Cancer

被引：6

作者：

Stojanovic, Bojan ^{[1
]}

Gajovic, Nevena ^{[2
]}

Jurisevic, Milena ^{[3
]}

Stojanovic, Milica Dimitrijevic ^{[2
,4
]}

Jovanovic, Marina ^{[5
]}

Jovanovic, Ivan ^{[2
]}

Stojanovic, Bojana S. ^{[2
,6
]}

Milosevic, Bojan ^{[1
]}

机构：

[1] Univ Kragujevac, Fac Med Sci, Dept Surg, Kragujevac 34000, Serbia

[2] Univ Kragujevac, Fac Med Sci, Ctr Mol Med & Stem Cell Res, Kragujevac 34000, Serbia

[3] Univ Kragujevac, Fac Med Sci, Dept Pharm, Kragujevac 34000, Serbia

[4] Univ Kragujevac, Fac Med Sci, Dept Pathol, Kragujevac 34000, Serbia

[5] Univ Kragujevac, Fac Med Sci, Dept Otorinolaringol, Kragujevac 34000, Serbia

[6] Univ Kragujevac, Fac Med Sci, Dept Pathophysiol, Kragujevac 34000, Serbia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 18期

关键词：

Interleukin-33; breast cancer; tumor microenvironment; immunotherapy; metastasis; TUMOR-GROWTH; CD8(+) T; CELLS; INTERLEUKIN-33; CYTOKINE; INNATE; ST2; MICROENVIRONMENT; ACTIVATION; EXPRESSION;

D O I：

10.3390/ijms241814026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-33 (IL-33) has emerged as a critical cytokine in the regulation of the immune system, showing a pivotal role in the pathogenesis of various diseases including cancer. This review emphasizes the role of the IL-33/ST2 axis in breast cancer biology, its contribution to cancer progression and metastasis, its influence on the tumor microenvironment and cancer metabolism, and its potential as a therapeutic target. The IL-33/ST2 axis has been shown to have extensive pro-tumorigenic features in breast cancer, starting from tumor tissue proliferation and differentiation to modulating both cancer cells and anti-tumor immune response. It has also been linked to the resistance of cancer cells to conventional therapeutics. However, the role of IL-33 in cancer therapy remains controversial due to the conflicting effects of IL-33 in tumorigenesis and anti-tumor response. The possibility of targeting the IL-33/ST2 axis in tumor immunotherapy, or as an adjuvant in immune checkpoint blockade therapy, is discussed.

引用

页数：16

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