Decoding the IL-33/ST2 Axis: Its Impact on the Immune Landscape of Breast Cancer

被引：6

作者：

Stojanovic, Bojan ^{[1
]}

Gajovic, Nevena ^{[2
]}

Jurisevic, Milena ^{[3
]}

Stojanovic, Milica Dimitrijevic ^{[2
,4
]}

Jovanovic, Marina ^{[5
]}

Jovanovic, Ivan ^{[2
]}

Stojanovic, Bojana S. ^{[2
,6
]}

Milosevic, Bojan ^{[1
]}

机构：

[1] Univ Kragujevac, Fac Med Sci, Dept Surg, Kragujevac 34000, Serbia

[2] Univ Kragujevac, Fac Med Sci, Ctr Mol Med & Stem Cell Res, Kragujevac 34000, Serbia

[3] Univ Kragujevac, Fac Med Sci, Dept Pharm, Kragujevac 34000, Serbia

[4] Univ Kragujevac, Fac Med Sci, Dept Pathol, Kragujevac 34000, Serbia

[5] Univ Kragujevac, Fac Med Sci, Dept Otorinolaringol, Kragujevac 34000, Serbia

[6] Univ Kragujevac, Fac Med Sci, Dept Pathophysiol, Kragujevac 34000, Serbia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 18期

关键词：

Interleukin-33; breast cancer; tumor microenvironment; immunotherapy; metastasis; TUMOR-GROWTH; CD8(+) T; CELLS; INTERLEUKIN-33; CYTOKINE; INNATE; ST2; MICROENVIRONMENT; ACTIVATION; EXPRESSION;

D O I：

10.3390/ijms241814026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-33 (IL-33) has emerged as a critical cytokine in the regulation of the immune system, showing a pivotal role in the pathogenesis of various diseases including cancer. This review emphasizes the role of the IL-33/ST2 axis in breast cancer biology, its contribution to cancer progression and metastasis, its influence on the tumor microenvironment and cancer metabolism, and its potential as a therapeutic target. The IL-33/ST2 axis has been shown to have extensive pro-tumorigenic features in breast cancer, starting from tumor tissue proliferation and differentiation to modulating both cancer cells and anti-tumor immune response. It has also been linked to the resistance of cancer cells to conventional therapeutics. However, the role of IL-33 in cancer therapy remains controversial due to the conflicting effects of IL-33 in tumorigenesis and anti-tumor response. The possibility of targeting the IL-33/ST2 axis in tumor immunotherapy, or as an adjuvant in immune checkpoint blockade therapy, is discussed.

引用

页数：16

共 76 条

[1] The Pleiotropic Immunomodulatory Functions of IL-33 and Its Implications in Tumor Immunity [J].

Afferni, Claudia ;

Buccione, Carla ;

Andreone, Sara ;

Galdiero, Maria Rosaria ;

Varricchi, Gilda ;

Marone, Gianni ;

Mattei, Fabrizio ;

Schiavoni, Giovanna .

FRONTIERS IN IMMUNOLOGY, 2018, 9

[2] Current and future burden of breast cancer: Global statistics for 2020 and 2040 [J].

Arnold, Melina ;

Morgan, Eileen ;

Rumgay, Harriet ;

Mafra, Allini ;

Singh, Deependra ;

Laversanne, Mathieu ;

Vignat, Jerome ;

Gralow, Julie R. ;

Cardoso, Fatima ;

Siesling, Sabine ;

Soerjomataram, Isabelle .

BREAST, 2022, 66 :15-23

[3] Current State of Breast Cancer Diagnosis, Treatment, and Theranostics [J].

Bhushan, Arya ;

Gonsalves, Andrea ;

Menon, Jyothi U. .

PHARMACEUTICS, 2021, 13 (05)

[4] IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer [J].

Blomberg, Olga S. ;

Spagnuolo, Lorenzo ;

Garner, Hannah ;

Voorwerk, Leonie ;

Isaeva, Olga I. ;

van Dyk, Ewald ;

Bakker, Noor ;

Chalabi, Myriam ;

Klaver, Chris ;

Duijst, Maxime ;

Kersten, Kelly ;

Bruggemann, Marieke ;

Pastoors, Dorien ;

Hau, Cheei-Sing ;

Vrijland, Kim ;

Raeven, Elisabeth A. M. ;

Kaldenbach, Daphne ;

Kos, Kevin ;

Afonina, Inna S. ;

Kaptein, Paulien ;

Hoes, Louisa ;

Theelen, Willemijn S. M. E. ;

Baas, Paul ;

Voest, Emile E. ;

Beyaert, Rudi ;

Thommen, Daniela S. ;

Wessels, Lodewyk F. A. ;

de Visser, Karin E. ;

Kok, Marleen .

CANCER CELL, 2023, 41 (01) :106-+

[5] IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo [J].

Carriere, Virginie ;

Roussel, Lucie ;

Ortega, Nathalie ;

Lacorre, Delphine-Armelle ;

Americh, Laure ;

Aguilar, Luc ;

Bouche, Gerard ;

Girard, Jean-Philippe .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (01) :282-287

[6] Interleukin-33 (IL-33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine [J].

Cayrol, Corinne ;

Girard, Jean-Philippe .

CYTOKINE, 2022, 156

[7] IL-33, an Alarmin of the IL-1 Family Involved in Allergic and Non Allergic Inflammation: Focus on the Mechanisms of Regulation of Its Activity [J].

Cayrol, Corinne .

CELLS, 2022, 11 (01)

[8] Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family [J].

Cayrol, Corinne ;

Girard, Jean-Philippe .

IMMUNOLOGICAL REVIEWS, 2018, 281 (01) :154-168

[9] Tumor-Derived IL33 Promotes Tissue-Resident CD8+ T Cells and Is Required for Checkpoint Blockade Tumor Immunotherapy [J].

Chen, Lujun ;

Sun, Runzi ;

Xu, Junchi ;

Zhai, Wensi ;

Zhang, Dachuan ;

Yang, Min ;

Yue, Cuihua ;

Chen, Yichao ;

Li, Song ;

Turnquist, Heth ;

Jiang, Jingting ;

Lu, Binfeng .

CANCER IMMUNOLOGY RESEARCH, 2020, 8 (11) :1381-1392

[10] Obesity-mediated upregulation of the YAP/IL33 signaling axis promotes aggressiveness and induces an immunosuppressive tumor microenvironment in breast cancer [J].

Dai, Jia-Zih ;

Yang, Ching-Chieh ;

Shueng, Pei-Wei ;

Wang, Yen-Ju ;

Huang, Chen-Shiuan ;

Chao, Yi-Chun ;

Chen, Cheng-Hsun ;

Lin, Cheng-Wei .

JOURNAL OF CELLULAR PHYSIOLOGY, 2023, 238 (05) :992-1005

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