Non-coding RNAs and exosomal non-coding RNAs in pituitary adenoma

被引：3

作者：

Rahimian, Neda ^{[1
,2
]}

Sheida, Amirhossein ^{[3
,4
]}

Rajabi, Mohammadreza ^{[5
]}

Heidari, Mohammad Mahdi ^{[4
,6
]}

Tobeiha, Mohammad ^{[3
,4
]}

Esfahani, Pegah Veradi ^{[3
,4
]}

Asouri, Sahar Ahmadi ^{[7
]}

Hamblin, Michael R. ^{[8
]}

Mohamadzadeh, Omid ^{[9
]}

Motamedzadeh, Alireza ^{[10
]}

Mahabady, Mahmood Khaksary ^{[11
]}

机构：

[1] Iran Univ Med Sci IUMS, Inst Endocrinol & Metab, Endocrine Res Ctr, Tehran, Iran

[2] Iran Univ Med Sci, Firoozgar Hosp, Sch Med, Dept Internal Med, Tehran, Iran

[3] Kashan Univ Med Sci, Student Res Comm, Kashan, Iran

[4] Kashan Univ Med Sci, Sch Med, Kashan, Iran

[5] Shiraz Univ Med Sci, Transplant Res Ctr, Dept Pathol, Shiraz, Iran

[6] Kashan Univ Med Sci, Fac Med, Dept Pediat, Kashan, Iran

[7] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Inst Basic Sci, Kashan, Iran

[8] Univ Johannesburg, Fac Hlth Sci, Laser Res Ctr, Doornfontein, South Africa

[9] Univ Tehran Med Sci, Imam Khomeini Hosp Complex, Dept Neurol Surg, Tehran, Iran

[10] Kashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran

[11] Kashan Univ Med Sci, Anat Sci Res Ctr, Inst Basic Sci, Kashan, Iran

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 248卷

关键词：

Pituitary adenomas; Non-coding RNAs; Exosomes; MicroRNAs; Long non-coding RNAs; Circular RNAs; EPITHELIAL-MESENCHYMAL TRANSITION; CELL-PROLIFERATION; DOWN-REGULATION; BREAST-CANCER; UP-REGULATION; PROMOTE PROLIFERATION; PANCREATIC-CANCER; SIGNALING PATHWAY; TUMOR-SUPPRESSOR; PROGNOSTIC VALUE;

D O I：

10.1016/j.prp.2023.154649

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Pituitary adenoma (PA) is the third most common primary intracranial tumor in terms of overall disease incidence. Although they are benign tumors, they can have a variety of clinical symptoms, but are mostly asymptomatic, which often leads to diagnosis at an advanced stage when surgical intervention is ineffective. Earlier identification of PA could reduce morbidity and allow better clinical management of the affected patients. Non coding RNAs (ncRNAs) do not generally code for proteins, but can modulate biological processes at the post transcriptional level through a variety of molecular mechanisms. An increased number of ncRNA expression profiles have been found in PAs. Therefore, understanding the expression patterns of different ncRNAs could be a promising method for developing non-invasive biomarkers. This review summarizes the expression patterns of dysregulated ncRNAs (microRNAs, long non-coding RNAs, and circular RNAs) involved in PA, which could one day serve as innovative biomarkers or therapeutic targets for the treatment of this neoplasia. We also discuss the potential molecular pathways by which the dysregulated ncRNAs could cause PA and affect its progression.

引用

页数：11

共 195 条

[1] Role of non-coding RNAs and exosomal non-coding RNAs in retinoblastoma progression [J].