Progressive multifocal leukoencephalopathy in a patient with relapsing multiple sclerosis treated with ocrelizumab: A case report

被引：0

作者：

Puig-Casadevall, Marc ^{[1
,2
]}

Alvarez-Bravo, Gary ^{[1
,2
,3
,10
]}

Varela, Ana Quiroga ^{[3
,4
]}

Robles-Cedeno, Rene ^{[1
,2
,4
,5
]}

Cirera, Laura Sanchez ^{[6
]}

Miguela, Albert ^{[3
,4
]}

Laguillo, Gemma ^{[7
]}

Montalban, Xavier ^{[8
]}

Hauser, Stephen L. ^{[9
]}

Ramio-Torrenta, Lluis ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Dr Josep Trueta Univ Hosp, Neurol Dept, Girona Neuroimmunol & Multiple Sclerosis Unit, Salt, Spain

[2] Santa Caterina Hosp, Salt, Spain

[3] Girona Biomed Res Inst IDIBGI, Neurodegenerat & Neuroinflammat Res Grp, Salt, Spain

[4] Inst Salud Carlos III, Redes Invest Cooperat Orientada Resultados Salud R, Red Enfermedades inflamatorias RD21 0002 0063, Madrid, Spain

[5] Univ Girona, Med Sci Dept, Girona, Spain

[6] Dr Josep Trueta Univ Hosp, Neurol Dept, Girona, Spain

[7] Dr Josep Trueta Univ Hosp, Radiol Dept, Girona, Spain

[8] Univ Autonoma Barcelona, Vall dHebron Hosp Univ, Vall dHebron Inst Recerca, Ctr Esclerosi Multiple Catalunya Cemcat,Serv Neuro, Barcelona, Spain

[9] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[10] Univ Hosp Josep Trueta, Dept Neurol, Unit Neuroimmunol & Multiple Sclerosis Girona, 10 Albereda St, Girona, Spain

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2023年 / 30卷 / 10期

关键词：

multiple sclerosis; ocrelizumab; pembrolizumab; progressive multifocal leukoencephalopathy; URINE;

D O I：

10.1111/ene.15988

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Progressive multifocal leukoencephalopathy is a rare but often fatal complication of some multiple sclerosis treatments. Although it has mainly been associated with natalizumab treatment, its appearance with other immunosuppressive therapies has also been reported.Aims: The aim of this case report is to describe the development of progressive multifocal encephalopathy in a patient with relapsing-remitting multiple sclerosis treated with ocrelizumab without previous use of natalizumab.Conclusions: A summary of the presentation and disease course is provided, presented in the context of the current literature and likely pathophysiology.

引用

页码：3357 / 3361

页数：5

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