Association between Serum Adiponectin and Insulin Resistance in Children and Adolescents with Type 1 Diabetes: A Cross-Sectional, Single Center Study from Egypt

Objective: To determine the serum level of adiponectin and its relation to insulin resistance (IR) in children and adolescents with type 1 diabetes (T1D).Materials and methods: Over a 3-month period, 65 children diagnosed with T1D who were followed up at the Diabetes Endocrine and Metabolism Pediatric Unit (DEMPU) at Cairo University Children's Hospital. Demographics, clinical data, investigations, and man-agement details were collected from the patient's medical records and evaluated for the serum level of adiponectin.Results: Mean age of the study population was 12.6 & PLUSMN; & PLUSMN; 2 years. About 40% of participants had low serum adiponectin, with a mean value of 2.4 & PLUSMN; 3.6. Sixty-one (93.8%) of participants had dyslipidemia. The mean estimated glucose disposal rate (eGDR) was 6.9 & PLUSMN; & PLUSMN; 2.1. Multivariate linear regression was performed to adjust for possible confounders in correlation between serum adiponectin and eGDR; it wasn't significant as p-value = 0.875. There was a statistically significant difference between patients with normal and low adi-ponectin regarding the age of diagnosis of diabetes, body mass index, the occurrence of microalbuminuria, and LDL level, with p-values of 0.04, 0.015, 0.022, and 0.011, respectively.Conclusions: There was also an association between lower adiponectin levels in children with type 1 diabetes and the occurrence of microalbuminuria and dyslipidemia. However, there is no reported associa-tion between its level and IR.