Kalihiacyloxyamides A-H, ?-acyloxy amide substituted kalihinane diterpenes isolated from the sponge Acanthella cavernosa collected in the South China Sea

被引：6

作者：

Wang, Zhe ^{[1
,2
]}

Li, Yueying ^{[3
]}

Han, Xian ^{[1
,2
]}

Zhang, Di ^{[1
,2
]}

Hou, Huiyue ^{[1
,2
]}

Xiao, Li ^{[1
,2
]}

Li, Guoqiang ^{[1
,2
]}

机构：

[1] Ocean Univ China, Chinese Minist Educ, Sch Med Pharm, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

[2] Natl Lab Marine Sci & Technol, Lab Marine Drugs & Biol Prod, Qingdao 266235, Peoples R China

[3] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA

来源：

PHYTOCHEMISTRY | 2023年 / 206卷

基金：

中国国家自然科学基金;

关键词：

Acanthella cavernosa; Dictyonellidae; Kalihinane diterpenes; Configuration determination; Cytotoxicity; ANTIMALARIAL ACTIVITY; ISONITRILES; ASSAY;

D O I：

10.1016/j.phytochem.2022.113512

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eight unreported alpha-acyloxy amide substituted kalihinane diterpenes, named kalihiacyloxyamides A-H were isolated from the South China Sea sponge Acanthella cavernosa. The planar structures and absolute configurations were elucidated by detailed 1D and 2D NMR experiments along with HRESIMS analysis, single crystal X-ray diffraction and CD spectroscopic analysis. Two compounds showed significant cytotoxicity against K562 cell line with IC50 values of 6.4 and 6.3 mu M, while two other compounds displayed moderate cytotoxicity against MDAMB-231 with IC50 values of 7.3 and 7.9 mu M.

引用

页数：8

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