Tumor-derived extracellular vesicle drug delivery system for chemo-photothermal-immune combination cancer treatment

被引：11

作者：

Bi, Yanghui ^{[1
]}

Chen, Jieya ^{[2
]}

Li, Qing ^{[1
]}

Li, Yan ^{[3
]}

Zhang, Ling ^{[4
,5
]}

Zhida, Liu ^{[6
]}

Yuan, Fajia ^{[7
]}

Zhang, Ruiping ^{[8
]}

机构：

[1] Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Hosp 3,Ctr Gene Sequencing, Taiyuan 030032, Peoples R China

[2] Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Shanxi Acad Med Sci,Hosp 3, Taiyuan 030032, Peoples R China

[3] Shanxi Med Univ, Sch Publ Hlth, Dept Epidemiol, Taiyuan 030001, Peoples R China

[4] Shanxi Med Univ, Dept Pathol, Taiyuan 030001, Shanxi, Peoples R China

[5] Shanxi Med Univ, Shanxi Key Lab Carcinogenesis & Translat Res Esoph, Taiyuan 030001, Shanxi, Peoples R China

[6] Shanxi Acad Adv Res & Innovat, Taiyuan 030032, Peoples R China

[7] Shanxi Jinzhong Hlth Sch, Jinzhong 030600, Peoples R China

[8] Shanxi Med Univ, Shanxi Prov Peoples Hosp, Hosp 5, Radiol Dept, Taiyuan 030001, Peoples R China

来源：

ISCIENCE | 2024年 / 27卷 / 02期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

CAMOUFLAGED MELANIN NANOPARTICLES; CELLS;

D O I：

10.1016/j.isci.2024.108833

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tumor extracellular vesicles (EVs) demonstrate considerable promise for medication delivery and tumor targeting owing to their natural long-term blood circulation and tissue targeting capabilities. We extracted EVs from mouse breast cancer cell 4T1 using UV stimulation and differential centrifugation. To create a new nano -drug delivery system, the vesicle delivery system (EPM) loaded with melanin and paclitaxel albumin (PA), the collected EVs were repeatedly compressed on a 200 nm porous polycarbonate membrane with melanin and PA. Our findings suggest that EPM is readily absorbed by breast cancer and dendritic cells. EPM generates significant photoacoustic signals and photothermal effects when exposed to near -infrared light and can enhance the infiltration of CD8+ T cells in mouse tumor tissues. EPM is more cytotoxic than PA in in vivo and in vitro investigations. The efficacy of EPM in clinical transformation when paired with chemotherapy/photothermal/immunotherapy treatment is demonstrated in this study.

引用

页数：16

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