HPV-related lesions after hysterectomy for high-grade cervical intraepithelial neoplasia and early-stage cervical cancer: A focus on the potential role of vaccination

被引：37

作者：

Bogani, Giorgio ^{[1
,14
]}

Sopracordevole, Francesco ^{[2
]}

Ciavattini, Andrea ^{[3
]}

Ghelardi, Alessandro ^{[4
]}

Vizza, Enrico ^{[5
]}

Vercellini, Paolo ^{[6
]}

Casarin, Jvan ^{[7
]}

Pinelli, Ciro ^{[7
]}

Ghezzi, Fabio ^{[7
]}

De Vincenzo, Rosa ^{[8
]}

Di Donato, Violante ^{[9
]}

Golia D'auge, Tullio ^{[9
]}

Giannini, Andrea ^{[9
]}

Sorbi, Flavia ^{[10
]}

Petrillo, Marco ^{[11
]}

Capobianco, Giampiero ^{[11
]}

Vizzielli, Giuseppe ^{[2
]}

Restaino, Stefano ^{[12
]}

Cianci, Stefano ^{[13
]}

Scambia, Giovanni ^{[8
]}

Raspagliesi, Francesco ^{[1
]}

机构：

[1] Fdn IRCCS Ist Nazl Tumori Milano, Gynecol Oncol Unit, Milan, Italy

[2] NCI, Gynecol Unit, Ctr Riferimento Oncol, Aviano, Italy

[3] Polytech Univ Marche, Womans Hlth Sci Dept, Gynecol Sect, Ancona, Italy

[4] Osped Apuane, UOC Ostetricia & Ginecol, Azienda Usl Toscana Nord Ovest, Massa, Italy

[5] IRCCS Regina Elena Natl Canc Inst, Dept Expt Clin Oncol, Gynecol Oncol Unit, Rome, Italy

[6] Fdn IRCCS CaGranda Osped Maggiore Policlin, Gynaecol Unit, Milan, Italy

[7] Univ Insubria, Filippo Ponte Hosp, Osped Circolo Fdn Macchi, Dept Obstet & Gynecol, Varese, Italy

[8] Fdn Policlin Univ A Gemelli, Dipartimento Salute Donna & Bambino & Salute Pubbl, UOC Ginecol Oncolog, IRCCS, I-00168 Rome, Italy

[9] Sapienza Univ Rome, Dept Gynecol Obstet & Urol Sci, Rome, Italy

[10] Univ Florence, Dept Obstet & Gynecol, Florence, Italy

[11] Univ Sassari, Dept Obstet & Gynecol, I-07100 Sassari, Italy

[12] Univ Udine, Univ Hosp Azienda Sanit Univ Friuli Cent, Dept Med Area DAME, Clin Obstret & Gynecol St Maria Misericordia, Udine, Italy

[13] Univ Messina, Dept Human Pathol Adult & Childhood, G Barresi Unit Gynecol & Obstet, Messina, Italy

[14] Sapienza Univ Rome, Dept Gynecol Obstetr & Urol Sci, Viale Regina Elena 328, I-00161 Rome, RM, Italy

来源：

TUMORI JOURNAL | 2024年 / 110卷 / 02期

关键词：

HPV; vaccination; cervical cancer; hysterectomy; GYNECOLOGICAL ONCOLOGY ESGO; EFC CONSENSUS STATEMENTS; VAGINAL DISEASE ISSVD; HUMAN-PAPILLOMAVIRUS; INTERNATIONAL SOCIETY; EUROPEAN FEDERATION; COLPOSCOPY; INFECTION; COLLEGE; ECSVD;

D O I：

10.1177/03008916231208344

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: To date, no data supports the execution of vaccination after hysterectomy for high-grade cervical intraepithelial neoplasia (CIN2+) and early-stage cervical cancer. We aim to evaluate the potential effect of vaccination after hysterectomy for high-grade cervical intraepithelial neoplasia and early-stage cervical cancer. Methods: This is a multi-center retrospective study evaluating data of women who develop lower genital tract dysplasia (including anal, vulvar and vaginal intra-epithelial neoplasia) after having hysterectomy for CIN2+ and FIGO stage IA1IB1 cervical cancer. Results: Overall, charts for 77 patients who developed lower genital tract dysplasia were collected. The study population included 62 (80.5%) and 15 (19.5%) patients with CIN2+ and early-stage cervical cancer, respectively. The median (range) time between hysterectomy and diagnosis of develop lower genital tract dysplasia was 38 (range, 14-62) months. HPV types covered by the nonavalent HPV vaccination would potentially cover 94.8% of the development of lower genital tract dysplasia. Restricting the analysis to the 18 patients with available HPV data at the time of hysterectomy, the beneficial effect of nonvalent vaccination was 89%. However, considering that patients with persistent HPV types (with the same HPV types at the time of hysterectomy and who developed lower genital tract dysplasia) would not benefit from vaccination, we estimated the potential protective effect of vaccination to be 67% (12 out of 18 patients; four patients had a persistent infection for the same HPV type(s)). Conclusions: Our retrospective analysis supported the adoption of HPV vaccination in patients having treatment for HPV-related disease. Even in the absence of the uterine cervix, HPV vaccination would protect against develop lower genital tract dysplasia. Further prospective studies have to confirm our preliminary research.

引用

页码：139 / 145

页数：7

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