Nebulized medications in the emergency department: A narrative review of nontraditional agents

被引:1
作者
Weant, Kyle A. [1 ]
Baum, Regan A. [2 ,3 ]
Hile, Garrett B. [2 ]
Humphries, Roger L. [4 ]
Metts, Elise L. [2 ,3 ]
Miller, Amy R. [5 ]
Woolum, Jordan A. [2 ,3 ]
Bailey, Abby M. [2 ,3 ]
机构
[1] Univ South Carolina, Dept Clin Pharm & Outcome Sci, Coll Pharm, Columbia, SC 29208 USA
[2] Univ Kentucky HealthCare, Lexington, KY USA
[3] Univ Kentucky, Coll Pharm, Lexington, KY USA
[4] Univ Kentucky HealthCare, Dept Emergency Med, Lexington, KY USA
[5] Univ South Carolina, Coll Pharm, Columbia, SC USA
关键词
administration; emergency service; inhalation; pharmacists; MAGNESIUM-SULFATE; HYDROFLUORIC-ACID; ACUTE ASTHMA; INTRAVENOUS MORPHINE; TRANEXAMIC ACID; INHALED FUROSEMIDE; MESH NEBULIZERS; DOUBLE-BLIND; ED PATIENTS; ACUTE PAIN;
D O I
10.1093/ajhp/zxad273
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Purpose This article summarizes emerging nontraditional therapies administered via the nebulization route for use in the emergency department (ED).Summary Although traditional routes of medication administration (eg, intravenous) have been the mainstay of administration modalities for decades, these routes may not be appropriate for all patients. Nowhere is this more readily apparent than in the ED setting, where patients with a variety of presentations receive care. One unique route for medication administration that has increasingly gained popularity in the ED is that of aerosolized drug delivery. This route holds promise as direct delivery of medications to the site of action could yield a more rapid and effective therapeutic response while also minimizing systemic adverse effects by utilizing a fraction of the systemic dose. Medication administration via nebulization also provides an alternative that is conducive to rapid, less invasive access, which is advantageous in the emergent setting of the ED. This review is intended to analyze the existing literature regarding this route of administration, including the nuances that can impact drug efficacy, as well as the available literature regarding novel, noncommercial nebulized medication therapy given in the ED.Conclusion Multiple medications have been investigated for administration via this route, and when implementing any of these therapies several practical considerations must be taken into account, from medication preparation to administration, to ensure optimal efficacy while minimizing adverse effects. The pharmacist is an essential bedside team member in these scenarios to assist with navigating unique and complex nuances of this therapy as they develop.
引用
收藏
页码:88 / 105
页数:18
相关论文
共 105 条
[41]  
Hill J, 1997, CLIN EXP ALLERGY, V27, P546, DOI 10.1046/j.1365-2222.1997.490854.x
[42]   Use of isotonic nebulised magnesium sulphate as an adjuvant to salbutamol in treatment of severe asthma in adults: randomised placebo-controlled trial [J].
Hughes, R ;
Goldkorn, A ;
Masoli, M ;
Weatherall, M ;
Burgess, C ;
Beasley, R .
LANCET, 2003, 361 (9375) :2114-2117
[43]   A retrospective analysis of nebulized versus intravenous fentanyl for renal colic [J].
Imamoglu, Melih ;
Aygun, Ali ;
Bekar, Omer ;
Erdem, Erkan ;
Cicek, Mustafa ;
Tatli, Ozgur ;
Karaca, Yunus ;
Sahin, Aynur ;
Turkmen, Suha ;
Turedi, Suleyman .
AMERICAN JOURNAL OF EMERGENCY MEDICINE, 2017, 35 (05) :757-763
[44]  
Jones R, 2010, WEST J EMERG MED, V11, P151
[45]   COVID-19 Acute Respiratory Distress Syndrome and Pulmonary Embolism: A Case Report of Nebulized Nitroglycerin and Systemic Thrombolysis For Right Ventricular Failure [J].
Karfunkle, Benjamin ;
Gill, Joseph ;
Shirey, Stephanie ;
Gordon, Richard .
JOURNAL OF EMERGENCY MEDICINE, 2021, 61 (05) :E103-E107
[46]   INHALED FUROSEMIDE IS NOT EFFECTIVE IN ACUTE ASTHMA [J].
KARPEL, JP ;
DWORKIN, F ;
HAGER, D ;
FELICIANO, S ;
SHAPIRO, D ;
POSNER, L ;
LUKS, D .
CHEST, 1994, 106 (05) :1396-1400
[47]   Inhaled magnesium sulfate in the treatment of acute asthma [J].
Knightly, Rachel ;
Milan, Stephen J. ;
Hughes, Rodney ;
Knopp-Sihota, Jennifer A. ;
Rowe, Brian H. ;
Normansell, Rebecca ;
Powell, Colin .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2017, (11)
[48]   Successful treatments of lung injury and skin burn due to hydrofluoric acid exposure [J].
Kono, K ;
Watanabe, T ;
Dote, T ;
Usuda, K ;
Nishiura, H ;
Tagawa, T ;
Tominaga, M ;
Higuchi, Y ;
Onnda, M .
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 2000, 73 (Suppl 1) :S93-S97
[49]   Pharmaceutical considerations in aerosol drug delivery [J].
Kuhn, RJ .
PHARMACOTHERAPY, 2002, 22 (03) :80S-85S
[50]   Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications [J].
Labiris, NR ;
Dolovich, MB .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2003, 56 (06) :588-599