Enhanced amygdala-cingulate connectivity associates with better mood in both healthy and depressive individuals after sleep deprivation

被引：14

作者：

Chai, Ya ^{[1
,2
,3
]}

Gehrman, Philip ^{[4
]}

Yu, Meichen ^{[5
,6
]}

Mao, Tianxin ^{[1
,2
,3
]}

Deng, Yao ^{[1
,2
,3
]}

Rao, Joy ^{[2
,3
]}

Shi, Hui ^{[2
,3
,7
]}

Quan, Peng ^{[2
,3
,8
]}

Xu, Jing ^{[1
,2
,3
]}

Zhang, Xiaocui ^{[2
,3
,9
]}

Lei, Hui ^{[2
,3
,10
]}

Fang, Zhuo ^{[2
,3
,11
]}

Xu, Sihua ^{[1
,2
,3
]}

Boland, Elaine ^{[4
,12
]}

Goldschmied, Jennifer R. ^{[4
]}

Barilla, Holly ^{[4
]}

Goel, Namni ^{[13
]}

Basner, Mathias ^{[14
]}

Thase, Michael E. ^{[4
,12
]}

Sheline, Yvette I. ^{[4
,15
]}

Dinges, David F. ^{[14
]}

Detre, John A. ^{[2
,3
]}

Zhang, Xiaochu ^{[1
,16
,17
]}

Rao, Hengyi ^{[1
,2
,3
]}

机构：

[1] Shanghai Int Studies Univ, Sch Business & Management, Key Lab Brain Machine Intelligence Informat Beh, Minist Educ & Shanghai, Shanghai 201620, Peoples R China

[2] Univ Penn, Ctr Funct Neuroimaging, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Neurol, Perelman Sch Med, Philadelphia, PA 19104 USA

[4] Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA

[5] Indiana Univ, Sch Med, Indiana Alzheimers Dis Res Ctr, Indianapolis, IN 46202 USA

[6] Indiana Univ, Network Sci Inst, Bloomington, IN 47408 USA

[7] Capital Med Univ, Beijing An Zhen Hosp, Beijing 100029, Peoples R China

[8] Guangdong Med Univ, Res Ctr Qual Life & Appl Psychol, Dongguan 524023, Guangdong, Peoples R China

[9] Cent South Univ, Xiangya Hosp 2, Med Psychol Ctr, Changsha 410017, Hunan, Peoples R China

[10] Hunan Agr Univ, Coll Educ, Changsha 410127, Hunan, Peoples R China

[11] Univ Ottawa, Brain & Mind Res Inst, Ottawa, ON K1H 8M5, Canada

[12] Corporal Michael J Crescenz Vet Affairs Med Ctr, Mental Illness Res Educ & Clin Ctr, Philadelphia, PA 19104 USA

[13] Rush Univ, Dept Psychiat & Behav Sci, Biol Rhythms Res Lab, Med Ctr, Chicago, IL 60612 USA

[14] Univ Penn, Perelman Sch Med, Dept Psychiat, Div Sleep & Chronobiol, Philadelphia, PA 19104 USA

[15] Univ Penn, Perelman Sch Med, Ctr Neuromodulat Depress & Stress, Philadelphia, PA 19104 USA

[16] Univ Sci & Technol China, Sch Life Sci, Affiliated Hosp 1, Div Life Sci & Med,Dept Radiol, Hefei 230026, Anhui, Peoples R China

[17] Univ Sci & Technol China, Dept Psychol, Sch Humanities & Social Sci, Hefei 230026, Anhui, Peoples R China

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2023年 / 120卷 / 26期

关键词：

sleep deprivation; mood; antidepressant effect; amygdala; functional connectivity; STATE FUNCTIONAL CONNECTIVITY; ANTERIOR CINGULATE; REGULATING CIRCUIT; GENDER-DIFFERENCES; VULNERABILITY; VARIABILITY; COGNITION; DISORDER; CORTEX; MRI;

D O I：

10.1073/pnas.2214505120

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sleep loss robustly disrupts mood and emotion regulation in healthy individuals but can have a transient antidepressant effect in a subset of patients with depression. The neural mechanisms underlying this paradoxical effect remain unclear. Previous studies suggest that the amygdala and dorsal nexus (DN) play key roles in depressive mood regulation. Here, we used functional MRI to examine associations between amygdala- and DN-related resting-state connectivity alterations and mood changes after one night of total sleep deprivation (TSD) in both healthy adults and patients with major depressive disorder using strictly controlled in-laboratory studies. Behavioral data showed that TSD increased negative mood in healthy participants but reduced depressive symptoms in 43% of patients. Imaging data showed that TSD enhanced both amygdala-and DN-related connectivity in healthy participants. Moreover, enhanced amygdala connectivity to the anterior cingulate cortex (ACC) after TSD associated with better mood in healthy participants and antidepressant effects in depressed patients. These findings support the key role of the amygdala-cingulate circuit in mood regulation in both healthy and depressed populations and suggest that rapid antidepressant treatment may target the enhancement of amygdala-ACC connectivity.

引用

页数：8