The role of resistance training and creatine supplementation on oxidative stress, antioxidant defense, muscle strength, and quality of life in older adults

被引:17
作者
Amiri, Ehsan [1 ]
Sheikholeslami-Vatani, Dariush [1 ]
机构
[1] Univ Kurdistan, Dept Sport Sci, Sanandaj, Iran
关键词
creatine; antioxidant defense; aging; quality of life; muscular endurance; AEROBIC EXERCISE; FREE-RADICALS; MARKERS; DAMAGE;
D O I
10.3389/fpubh.2023.1062832
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
BackgroundThe aim of this study was to evaluate the effect of resistance training (RT) with creatine monohydrate supplementation (CS) on serum levels of 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA), glutathione peroxidase (GPX), and total antioxidant capacity (TAC) in older adults. ObjectivesThis study evaluated the effect of resistance training with creatine monohydrate supplementation on oxidative stress and antioxidant defense, muscle strength and quality of life in older adults. MethodsWe examined 45 non-athlete volunteer older men and women (mean, 68.1 +/- 7.2 years old), were randomly selected and divided into three groups of 15: RT with creatine supplementation (RT + CS), RT with placebo (RT + P) and control group. RT protocol was performed for 10 weeks, three sessions per week. Creatine supplement was taken daily at a dose of 0.1 g/kg of body weight, while the placebo group consumed the same amount of starch. Fasting blood samples were taken before the start of program and at the end of the RT period. ResultsIn the training groups, after 10 weeks of RT, a significant decrease in MDA and 8 - OHDG as well as a significant increase in serum levels of GPX and TAC were observed (in all cases, p = 0.001). In addition, creatinine levels were enhanced in the RT + CS (p = 0.014). Training intervention also improved quality of life and muscle strength in the experimental groups (p = 0.001), although muscle strength changes were more visible in the RT + CS group than in the RT + P group (p < 0/05). ConclusionRegular resistance training can be recommended as a very suitable non-pharmacological approach to strengthen the body's antioxidant system, muscle strength and quality of life in older adults. There are no definite findings on the role of creatine on the antioxidant system and quality of life in older adults, but the use of this supplement in addition to RT can double the amount of strength gained from resistance training.
引用
收藏
页数:8
相关论文
共 39 条
[11]   EFFECT OF A RESISTANCE TRAINING PROGRAM ON SARCOPENIA AND FUNCTIONALITY OF THE OLDER ADULTS LIVING IN A NURSING HOME [J].
Del Campo Cervantes, J. Martin ;
Macias Cervantes, M. Habacuc ;
Monroy Torres, R. .
JOURNAL OF NUTRITION HEALTH & AGING, 2019, 23 (09) :829-836
[12]   Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans [J].
Deminice, Rafael ;
Rosa, Flavia Troncon ;
Franco, Gabriel Silveira ;
Jordao, Alceu Afonso ;
de Freitas, Ellen Cristini .
NUTRITION, 2013, 29 (09) :1127-1132
[13]   The reversal of fortunes: Trends in county mortality and cross-county mortality disparities in the United States [J].
Ezzati, Majid ;
Friedman, Ari B. ;
Kulkarni, Sandeep C. ;
Murray, Christopher J. L. .
PLOS MEDICINE, 2008, 5 (04) :557-568
[14]  
Fehrenbach E, 2001, EXERC IMMUNOL REV, V7, P66
[15]  
Ghahremani Moghadam M., 2018, MED LAB J, V12, P17, DOI [10.29252/mlj.12.3.17, DOI 10.29252/MLJ.12.3.17]
[16]   Calcium and ROS: A mutual interplay [J].
Goerlach, Agnes ;
Bertram, Katharina ;
Hudecova, Sona ;
Krizanova, Olga .
REDOX BIOLOGY, 2015, 6 :260-271
[17]   NITRATE BIOSYNTHESIS IN MAN [J].
GREEN, LC ;
DELUZURIAGA, KR ;
WAGNER, DA ;
RAND, W ;
ISTFAN, N ;
YOUNG, VR ;
TANNENBAUM, SR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (12) :7764-7768
[18]   The Epidemiology of Sarcopenia [J].
Janssen, Ian .
CLINICS IN GERIATRIC MEDICINE, 2011, 27 (03) :355-+
[19]   Prediction of mycoplasma hominis proteins targeting in mitochondria and cytoplasm of host cells and their implication in prostate cancer etiology [J].
Khan, Shahanavaj ;
Zakariah, Mohammed ;
Rolfo, Christian ;
Robrecht, Lembrechts ;
Palaniappan, Sellappan .
ONCOTARGET, 2017, 8 (19) :30830-30843
[20]   Role of creatine supplementation on exercise-induced cardiovascular function and oxidative stress [J].
Kingsley, Michael I. C. ;
Cunningham, Daniel ;
Mason, Laura ;
Kilduff, Liam P. ;
McEneny, Jane .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2009, 2 (04) :247-254