Sodium-glucose co-transporter 2 (SGLT2) inhibitors represent one type of new-generation type 2 diabetes (T2DM) drug treatment. The mechanism of action of an SGLT2 inhibitor (SGLT2i) in treating T2DM depends on lowering blood glucose levels effectively via increasing the glomerular excretion of glucose. A good number of randomized clinical trials revealed that SGLT2is significantly prevented heart failure (HF) and cardiovascular death in T2DM patients. Despite ongoing clinical trials in HF patients without T2DM, there have been a limited number of translational studies on the cardioprotective properties of SGLT2is. As the cellular mechanism behind the cardiac benefits of SGLT2is is still to be elucidated, animal models are used to better understand the pathways behind the cardioprotective mechanism of SGLT2i. In this review, we summarize the animal models constructed to study the cardioprotective mechanisms of SGLT2is to help deliver a more comprehensive understanding of the in vivo work that has been done in this field and to help select the most optimal animal model to use when studying the different cardioprotective effects of SGLT2is.
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Aubert, Gregory
Martin, Ola J.
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h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Martin, Ola J.
Horton, Julie L.
论文数: 0引用数: 0
h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Horton, Julie L.
Lai, Ling
论文数: 0引用数: 0
h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Lai, Ling
Vega, Rick B.
论文数: 0引用数: 0
h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Vega, Rick B.
Leone, Teresa C.
论文数: 0引用数: 0
h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Leone, Teresa C.
Koves, Timothy
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Dept Med, Durham, NC USA
Duke Univ, Dept Pharmacol, Durham, NC USA
Duke Univ, Dept Canc Biol, Durham, NC USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Koves, Timothy
Gardell, Stephen J.
论文数: 0引用数: 0
h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Gardell, Stephen J.
Krueger, Marcus
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cologne, Inst Genet, CECAD Res Ctr, D-50931 Cologne, GermanySanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Krueger, Marcus
Hoppel, Charles L.
论文数: 0引用数: 0
h-index: 0
机构:
Case Western Reserve Univ, Dept Pharmacol, Cleveland, OH 44106 USA
Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Hoppel, Charles L.
Lewandowski, E. Douglas
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Coll Med, Chicago, IL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Lewandowski, E. Douglas
Crawford, Peter A.
论文数: 0引用数: 0
h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Washington Univ, Sch Med, Dept Med, St Louis, MO USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Crawford, Peter A.
Muoio, Deborah M.
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Dept Med, Durham, NC USA
Duke Univ, Dept Pharmacol, Durham, NC USA
Duke Univ, Dept Canc Biol, Durham, NC USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Muoio, Deborah M.
Kelly, Daniel P.
论文数: 0引用数: 0
h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
机构:
Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USA
Univ Illinois, Div Nutrit Sci, Urbana, IL 61801 USAUniv Illinois, Dept Anim Sci, Urbana, IL 61801 USA
机构:
New York Univ Langone Hlth, Dept Med, New York, NY USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Basu, Debapriya
Hu, Yunying
论文数: 0引用数: 0
h-index: 0
机构:
New York Univ Langone Hlth, Dept Med, New York, NY USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Hu, Yunying
Huggins, Lesley-Ann
论文数: 0引用数: 0
h-index: 0
机构:
New York Univ Langone Hlth, Dept Med, New York, NY USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Huggins, Lesley-Ann
Mullick, Adam E.
论文数: 0引用数: 0
h-index: 0
机构:
Ionis Pharmaceut, Carlsbad, CA USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Mullick, Adam E.
Graham, Mark J.
论文数: 0引用数: 0
h-index: 0
机构:
Ionis Pharmaceut, Carlsbad, CA USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Graham, Mark J.
Wietecha, Tomasz
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Med, Div Cardiol, Seattle, WA 98195 USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Wietecha, Tomasz
Barnhart, Shelley
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, UW Diabet Inst, Seattle, WA 98195 USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Barnhart, Shelley
Mogul, Allison
论文数: 0引用数: 0
h-index: 0
机构:
New York Univ Langone Hlth, Dept Med, New York, NY USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Mogul, Allison
Pfeiffer, Katharina
论文数: 0引用数: 0
h-index: 0
机构:
Freiburg Univ, Heart Ctr, Dept Cardiol & Angiol 1, Freiburg, GermanyNew York Univ Langone Hlth, Dept Med, New York, NY USA
Pfeiffer, Katharina
Zirlik, Andreas
论文数: 0引用数: 0
h-index: 0
机构:
Freiburg Univ, Heart Ctr, Dept Cardiol & Angiol 1, Freiburg, GermanyNew York Univ Langone Hlth, Dept Med, New York, NY USA
Zirlik, Andreas
Fisher, Edward A.
论文数: 0引用数: 0
h-index: 0
机构:
New York Univ Langone Hlth, Dept Med, New York, NY USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Fisher, Edward A.
Bornfeldt, Karin E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, UW Diabet Inst, Seattle, WA 98195 USA
Univ Washington, Dept Pathol, Seattle, WA 98195 USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Bornfeldt, Karin E.
Willecke, Florian
论文数: 0引用数: 0
h-index: 0
机构:
Freiburg Univ, Heart Ctr, Dept Cardiol & Angiol 1, Freiburg, GermanyNew York Univ Langone Hlth, Dept Med, New York, NY USA
Willecke, Florian
Goldberg, Ira J.
论文数: 0引用数: 0
h-index: 0
机构:
New York Univ Langone Hlth, Dept Med, New York, NY USANew York Univ Langone Hlth, Dept Med, New York, NY USA
机构:
Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Bisignano, Paola
Ghezzi, Chiara
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Ghezzi, Chiara
Jo, Hyunil
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Jo, Hyunil
Polizzi, Nicholas F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Polizzi, Nicholas F.
Althoff, Thorsten
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Althoff, Thorsten
Kalyanaraman, Chakrapani
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Kalyanaraman, Chakrapani
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机构:
Friemann, Rosmarie
Jacobson, Matthew P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Jacobson, Matthew P.
Wright, Ernest M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Wright, Ernest M.
Grabe, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Aubert, Gregory
Martin, Ola J.
论文数: 0引用数: 0
h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Martin, Ola J.
Horton, Julie L.
论文数: 0引用数: 0
h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Horton, Julie L.
Lai, Ling
论文数: 0引用数: 0
h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Lai, Ling
Vega, Rick B.
论文数: 0引用数: 0
h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Vega, Rick B.
Leone, Teresa C.
论文数: 0引用数: 0
h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Leone, Teresa C.
Koves, Timothy
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Dept Med, Durham, NC USA
Duke Univ, Dept Pharmacol, Durham, NC USA
Duke Univ, Dept Canc Biol, Durham, NC USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Koves, Timothy
Gardell, Stephen J.
论文数: 0引用数: 0
h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Gardell, Stephen J.
Krueger, Marcus
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cologne, Inst Genet, CECAD Res Ctr, D-50931 Cologne, GermanySanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Krueger, Marcus
Hoppel, Charles L.
论文数: 0引用数: 0
h-index: 0
机构:
Case Western Reserve Univ, Dept Pharmacol, Cleveland, OH 44106 USA
Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Hoppel, Charles L.
Lewandowski, E. Douglas
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Coll Med, Chicago, IL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Lewandowski, E. Douglas
Crawford, Peter A.
论文数: 0引用数: 0
h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Washington Univ, Sch Med, Dept Med, St Louis, MO USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Crawford, Peter A.
Muoio, Deborah M.
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Dept Med, Durham, NC USA
Duke Univ, Dept Pharmacol, Durham, NC USA
Duke Univ, Dept Canc Biol, Durham, NC USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
Muoio, Deborah M.
Kelly, Daniel P.
论文数: 0引用数: 0
h-index: 0
机构:
Sanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USASanford Burnham Prebys Med Discovery Inst, Cardiovasc Metab Program, Orlando, FL USA
机构:
Univ Illinois, Dept Anim Sci, Urbana, IL 61801 USA
Univ Illinois, Div Nutrit Sci, Urbana, IL 61801 USAUniv Illinois, Dept Anim Sci, Urbana, IL 61801 USA
机构:
New York Univ Langone Hlth, Dept Med, New York, NY USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Basu, Debapriya
Hu, Yunying
论文数: 0引用数: 0
h-index: 0
机构:
New York Univ Langone Hlth, Dept Med, New York, NY USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Hu, Yunying
Huggins, Lesley-Ann
论文数: 0引用数: 0
h-index: 0
机构:
New York Univ Langone Hlth, Dept Med, New York, NY USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Huggins, Lesley-Ann
Mullick, Adam E.
论文数: 0引用数: 0
h-index: 0
机构:
Ionis Pharmaceut, Carlsbad, CA USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Mullick, Adam E.
Graham, Mark J.
论文数: 0引用数: 0
h-index: 0
机构:
Ionis Pharmaceut, Carlsbad, CA USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Graham, Mark J.
Wietecha, Tomasz
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Med, Div Cardiol, Seattle, WA 98195 USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Wietecha, Tomasz
Barnhart, Shelley
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, UW Diabet Inst, Seattle, WA 98195 USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Barnhart, Shelley
Mogul, Allison
论文数: 0引用数: 0
h-index: 0
机构:
New York Univ Langone Hlth, Dept Med, New York, NY USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Mogul, Allison
Pfeiffer, Katharina
论文数: 0引用数: 0
h-index: 0
机构:
Freiburg Univ, Heart Ctr, Dept Cardiol & Angiol 1, Freiburg, GermanyNew York Univ Langone Hlth, Dept Med, New York, NY USA
Pfeiffer, Katharina
Zirlik, Andreas
论文数: 0引用数: 0
h-index: 0
机构:
Freiburg Univ, Heart Ctr, Dept Cardiol & Angiol 1, Freiburg, GermanyNew York Univ Langone Hlth, Dept Med, New York, NY USA
Zirlik, Andreas
Fisher, Edward A.
论文数: 0引用数: 0
h-index: 0
机构:
New York Univ Langone Hlth, Dept Med, New York, NY USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Fisher, Edward A.
Bornfeldt, Karin E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, UW Diabet Inst, Seattle, WA 98195 USA
Univ Washington, Dept Pathol, Seattle, WA 98195 USANew York Univ Langone Hlth, Dept Med, New York, NY USA
Bornfeldt, Karin E.
Willecke, Florian
论文数: 0引用数: 0
h-index: 0
机构:
Freiburg Univ, Heart Ctr, Dept Cardiol & Angiol 1, Freiburg, GermanyNew York Univ Langone Hlth, Dept Med, New York, NY USA
Willecke, Florian
Goldberg, Ira J.
论文数: 0引用数: 0
h-index: 0
机构:
New York Univ Langone Hlth, Dept Med, New York, NY USANew York Univ Langone Hlth, Dept Med, New York, NY USA
机构:
Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Bisignano, Paola
Ghezzi, Chiara
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Ghezzi, Chiara
Jo, Hyunil
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Jo, Hyunil
Polizzi, Nicholas F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Polizzi, Nicholas F.
Althoff, Thorsten
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Althoff, Thorsten
Kalyanaraman, Chakrapani
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Kalyanaraman, Chakrapani
论文数: 引用数:
h-index:
机构:
Friemann, Rosmarie
Jacobson, Matthew P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Jacobson, Matthew P.
Wright, Ernest M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Wright, Ernest M.
Grabe, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USAUniv Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA