Therapeutic Potential of Natural Compounds in Neurodegenerative Diseases: Insights from Clinical Trials

被引：27

作者：

Andrade, Stephanie ^{[1
,2
]}

Nunes, Debora ^{[1
,2
]}

Dabur, Meghna ^{[1
,2
]}

Ramalho, Maria J. ^{[1
,2
]}

Pereira, Maria C. ^{[1
,2
]}

Loureiro, Joana A. ^{[1
,2
]}

机构：

[1] Univ Porto, Fac Engn, LEPABE Lab Proc Engn Environment Biotechnol & Ener, Rua Dr, P-4200465 Porto, Portugal

[2] Univ Porto, Fac Engn, ALiCE Associate Lab Chem Engn, Rua Dr Roberto Frias, P-4200465 Porto, Portugal

来源：

PHARMACEUTICS | 2023年 / 15卷 / 01期

关键词：

natural product; dietary supplement; cognitive function; human study; clinical study; MODERATE ALZHEIMERS-DISEASE; MULTIPLE-SCLEROSIS PATIENTS; VITAMIN-A SUPPLEMENTATION; DOUBLE-BLIND; PARKINSON DISEASE; AMYLOID-BETA; MOUSE MODEL; MOLECULAR-MECHANISMS; HUNTINGTONS-DISEASE; COGNITIVE DECLINE;

D O I：

10.3390/pharmaceutics15010212

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neurodegenerative diseases are caused by the gradual loss of neurons' function. These neurological illnesses remain incurable, and current medicines only alleviate the symptoms. Given the social and economic burden caused by the rising frequency of neurodegenerative diseases, there is an urgent need for the development of appropriate therapeutics. Natural compounds are gaining popularity as alternatives to synthetic drugs due to their neuroprotective properties and higher biocompatibility. While natural compounds' therapeutic effects for neurodegenerative disease treatment have been investigated in numerous in vitro and in vivo studies, only few have moved to clinical trials. This article provides the first systematic review of the clinical trials evaluating natural compounds' safety and efficacy for the treatment of the five most prevalent neurodegenerative disorders: Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease.

引用

页数：25

共 138 条

[1] High-dose B vitamin supplementation and cognitive decline in Alzheimer disease - A randomized controlled trial [J].

Aisen, Paul S. ;

Schneider, Lon S. ;

Sano, Mary ;

Diaz-Arrastia, Ramon ;

van Dyck, Christopher H. ;

Weiner, Myron F. ;

Bottiglieri, Teodoro ;

Jin, Shelia ;

Stokes, Karen T. ;

Thomas, Ronald G. ;

Thal, Leon J. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 300 (15) :1774-1783

[2] Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study) [J].

Aisen, Paul S. ;

Gauthier, Serge ;

Ferris, Steven H. ;

Saumier, Daniel ;

Haine, Denis ;

Garceau, Denis ;

Anh Duong ;

Suhy, Joyce ;

Oh, Joonmi ;

Lau, Wan C. ;

Sampalis, John .

ARCHIVES OF MEDICAL SCIENCE, 2011, 7 (01) :102-111

[3] Effect of omega-3 fatty acids and fish oil supplementation on multiple sclerosis: a systematic review [J].

AlAmmar, Welayah Ali ;

Albeesh, Fatima Hassan ;

Ibrahim, Layla Makki ;

Algindan, Yasmin Yussuf ;

Yamani, Lamya Zohair ;

Khattab, Rabie Yousif .

NUTRITIONAL NEUROSCIENCE, 2021, 24 (07) :569-579

[4]

alar D.S., 2020, REV MOL, V25, P3926

[5] The effect of exercise, yoga and physiotherapy on the quality of life of people with multiple sclerosis: Systematic review and meta-analysis [J].

Alphonsus, Khrisha B. ;

Su, Yingying ;

D'Arcy, Carl .

COMPLEMENTARY THERAPIES IN MEDICINE, 2019, 43 :188-195

[6]

Andrade Stephanie, 2015, 2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG). Proceedings, P1, DOI 10.1109/ENBENG.2015.7088833

[7] Natural Compounds for Alzheimer's Disease Therapy: A Systematic Review of Preclinical and Clinical Studies [J].

Andrade, Stephanie ;

Ramalho, Maria Joao ;

Loureiro, Joana Angelica ;

Pereira, Maria do Carmo .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (09)

[8] Effectiveness of the Combination of Memantine Plus Vitamin D on Cognition in Patients With Alzheimer Disease: A Pre-Post Pilot Study [J].

Annweiler, Cedric ;

Herrmann, Francois R. ;

Fantino, Bruno ;

Brugg, Bernard ;

Beauchet, Olivier .

COGNITIVE AND BEHAVIORAL NEUROLOGY, 2012, 25 (03) :121-127

[9]

[Anonymous], ID NCT00580931

[10] Natural products in drug discovery: advances and opportunities [J].

Atanasov, Atanas G. ;

Zotchev, Sergey B. ;

Dirsch, Verena M. ;

Supuran, Claudiu T. .

NATURE REVIEWS DRUG DISCOVERY, 2021, 20 (03) :200-216

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